The role of the NLRP3 inflammasome in gout. J Inflamm Res. 2011;4:39-49.Kingsbury, S. R.; Conaghan, P. G.; McDermott, M. F. The role of the NLRP3 inflammasome in gout. J. Inflamm. Res. 4: 39-49, 2011.Kingsbury, S. R., Conaghan, P. G., & McDermott, M. F. (2011)....
The inflammasome, a multiprotein complex central to inflammation-related diseases, is particularly exemplified by the NOD-like receptor protein 3 (NLRP3) inflammasome. Activated by various stimuli, the NLRP3 inflammasome takes part in the regulation of inflammatory responses and has been implicated in ...
Our results showed that hypoxia also induced the secretion of IL-1尾 in PC3, BPH-1 and RWPE-1 cells. Third, we found that NLRP3 inflammasome activation involved in regulating tumor growth and metastasis. Our results indicated that the activation of NLRP3 inflammation plays an important role ...
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that s
There are different types of inflammasomes, although the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is the most common inflammasome; NLRP3 plays an important role in the pathogenesis of neurodegenerative diseases. In this review, we will ...
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory
The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrate
role during the pathophysiology of neuroinflammation in age-related neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). The neurotransmitter dopamine (DA) is one of the players that negatively modulate NLRP3 inflammasome activation through DA receptors expressed in both microglia...
Here, we focus on recent advances on the potential role of NLRP3 inflammasome activation in the progression of CLD, including viral hepatitis, non-alcoholic steatohepatitis and alcoholic liver disease, and in particular, its ability to alleviate liver inflammation in animal models. Additionally, we ...
d colorectal cancer Critical role for the NLRP3 inflammasome in colitis and colitis associated colorectal cancerCritical role for the NLRP3 inflammasome in colitis and colitis associated colorectal cancerZaki, MohammadKanneganti, ThirumalaDevi