Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors Nat. Med., 15 (2009), pp. 1170-1178 CrossrefView in ScopusGoogle Scholar Greathouse et al., 2018 K.L. Greathouse, J.R. White, A.J. Vargas, V.V. Bliskovsky, J.A. ...
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Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial dynamics in mitigating such processes and their impact on muscle fitness rem
10]. In AD, activation of NLRP3 inflammasome has been shown to contribute to pathology progression by decreasing the phagocytic capacity of microglia [11,12]. Accordingly, its inhibition primes microglia to a neuroprotective phenotype, resulting in decreased deposition of...
NLRP3 (19771-1-AP) was from Proteintech (Chicago, United States). LPL antibody (16252), ATGL Early Cd exposure worsens HFD-induced MASLD to MASH During 10-week exposure, no appreciable differences in weekly food consumption were observed among groups. First, levels of Cd were determined in...
Pyroptosis was independent of the Nlrp3 and Nlrc4 inflammasome receptors but dependent on the inflammasome adaptor ASC and the cytosolic DNA sensor AIM2. Importantly, wild-type L. monocytogenes were also found to lyse, albeit at low levels, and trigger AIM2-dependent pyroptosis. These data ...
Peer Review reports Introduction Gut microbiota has a pivotal role in the regulation of human physiology and the bidirectional pathways of the gut-brain axis are involved in many neurological diseases and their role in migraine has gained attention in recent years. Factors such as the microbiota com...
SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense, whereas the role of Cl− signaling pathway in modulating pulmonary inflammation associate
Previous findings have shown that non-muscle myosin heavy-chain IIA (NMMHC IIA) is involved in autophagy induction triggered by starvation in D. melanogaster; however, its functional contribution to neuronal autophagy remains unclear. The aim of this stu
Pyroptosis is mediated by the formation of inflammasome complexes, which are cytosolic heptameric oligomers composed of the nucleotide-binding domain and leucine-rich repeat (NLR) pattern recognition receptors. The best-characterized NLR, NLRP3, is a redox-sensitive cytosolic sensor, which triggers the...