L. and Sahebkar, A. (2018) Role of the NLRP3 inflammasome in cancer. Mol Cancer 17, 158.Moossavi M, Parsamanesh N, Bahrami A, Atkin SL, Sahebkar A. Role of the NLRP3 inflammasome in cancer. Mol Cancer. 2018;17(1):158.
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subse...
IL-1尾 levels in tumor tissues were previously connected to poor prognosis for cancer patients. However, it remains unclear the function of inflammasomes in tumor growth and metastasis. The aim of this study is to examine whether the activation of NLRP3 inflammasome regulates the progression of ...
An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that s
d colorectal cancer Critical role for the NLRP3 inflammasome in colitis and colitis associated colorectal cancerCritical role for the NLRP3 inflammasome in colitis and colitis associated colorectal cancerZaki, MohammadKanneganti, ThirumalaDevi
Role of the NLRP3 inflammasome in cancer 2018, Molecular Cancer Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? 2015, Antioxidants and Redox Signaling A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases 2015, Nature Medicine The adaptor...
(NLRP3), apoptosis-associated speck–like protein (ASC) and pro-caspase-1. Different stimuli mediate NLRP3 activation, resulting in the NLRP3 inflammasome assembly and the pro-inflammatory cytokine (IL-1β and IL-18) maturation and secretion. The persistent and uncontrolled NLRP3 inflammasome ...
The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction. Front Cell Neurosci 2019;13:73. https://doi.org/10.3389/fncel.2019.00073. Thorburn A. Crosstalk between autophagy and apoptosis: Mechanisms ...
The inflammasome, a multiprotein complex central to inflammation-related diseases, is particularly exemplified by the NOD-like receptor protein 3 (NLRP3) inflammasome. Activated by various stimuli, the NLRP3 inflammasome takes part in the regulation of inflammatory responses and has been implicated in...
Many studies have focused on the NLRP3 inflammasome and this inflammasome is activated by a wide variety of cellular alarm signals. Once activated, caspase-1 is cleaved, inducing the secretion of IL-1β and IL-18 that signal to aid in the clearance of invading organisms. However, as the ...