Colorectal cancerInflammasomeInflammationNLRP3All phases of carcinogenesis are affected by inflammation. Activation of the inflammasome is a crucial signaling mechanism that leads to acute and chronic inflammation. When specific nucleotide-binding domains, leucine-rich repeat-containing proteins (NLRs) are ...
The NLRP3 inflammasome is an important sensor and indicator not only of inflammatory immune disorders but also of metabolic disorders, cardiovascular diseases, and respiratory ailments, which primarily constitute lifestyle diseases (Fig.4). Lifestyle factors such as diet, exercise, and exposure to env...
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in response to cellular perturbations. This assembly leads to the activation of caspase-1, which promotes maturation and release of the inflammatory cytokines interleukin-1β
and cancer development or In breast cancer, the NLRP3 inflammasome and IL-1β production promote the infiltration of myeloid cells, providing an inflammatory microenvironment that promotes breast cancer progression [22]. On the other hand, the NLRP3 inflammasome can inhibit tumorigenesis in colitis-as...
大家好,今天要和大家分享的是2021年7月online的一篇文章:“Pan-cancer analysis of NLRP3 inflammasome with potential implications in prognosis and immunotherapy in human cancer”。 NLRP3炎症小体可通过调节宿主免疫从而影响免疫治疗反应,是肿瘤发展过程中的一把双刃剑。然而,现代研究仍缺乏对人类癌症中NLRP3炎症小...
It is widely accepted that inflammation is an important risk for the development of prostate cancer (PCa). The objective of this study was designed to investigate the potential molecular mechanism of NLR family, pyrin domain-containing protein 3 (NLRP3) inflammasome in the malignant progression of...
IL-1尾 levels in tumor tissues were previously connected to poor prognosis for cancer patients. However, it remains unclear the function of inflammasomes in tumor growth and metastasis. The aim of this study is to examine whether the activation of NLRP3 inflammasome regulates the progression of ...
25. Sharma BR, Karki R, Kanneganti TD. Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol. 2019 Nov;49(11):1998–2011. 26. Downs KP, Nguyen H, Dorfleutner A, Stehlik C. ...
应用GEPIA和KM-plotter数据库分别对上述筛选出的基因表达水平与肝癌患者总体生存率之间进行分析。进入GEPIA数据库后,在survival analysis界面设置Gene为筛选出的DEGs,Datasets为LIHC,输出即可。进入KM-plotter数据库后,在liver cancer RNA-seq界...
The NLRP3 inflammasome is activated by mitochondrial damage and contributes to kidney fibrosis. However, it is unknown whether PGC-1α, a key mitochondrial biogenesis regulator, modulates NLRP3 inflammasome in kidney injury. Primary renal tubular epithel