参考文献: o Targeting the NLRP3 inflammasome in inflammatory diseases o The NLRP3–inflammasome as a sensor of organelle dysfunction o The NLRP3 inflammasome: molecular activation and regulation to therapeutics o Inflammasomes and Their Roles in Health and Disease o Alternative polyadenylation trans-fact...
NLRP3 inflammasome, Inflammatory bowel diseases, Mucosal immune system, Interleukin 1β, Interleukin 18, NLRP3 gene polymorphismsInflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a...
目前,NLRP3蛋白调控是领域内的研究热点,现有研究多集中在转录后水平和翻译后修饰水平,关于NLRP3转录激活的调控机制仍然有待阐明。 近期,国际期刊Cellular and Molecular Immunology发表了中国科学院昆明动物研究所姚永刚团队题为GSNOR negativel...
IPAF and AIM2 inflammasomes are linked a number of diseases such as familial periodic self-inflammation,gout,T2D which can provide some new targets for clinical treatment.This review will mainly introduce the composition,distribution and regulatory mechanism of inflammasome and inflammatory diseases ...
[1] Marin J J, Macias R I, Briz O, et al. Bile acids in physiology, pathology and pharmacology[J]. Curr Drug Metab, 2015, 17(1): 4-29. [2] Zhen Y, Zhang H. NLRP3 inflammasome and inflammatory bowel dis...
“科学突破奖”之庄小威、陈志坚)的美国德克萨斯大学西南医学中心的陈志坚(Zhijian 'James' Chen)研究组在Nature上在线发表了题为PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation的重量级研究文章(Article),解开了一个困扰学术界多年的谜题: NLRP3炎症小体是如何凭借一己之力识别大量...
Chestnut Studying 摘要 Inhibition of NLRP3 inflammasome activation produces potent therapeutic effects in a wide array of inflammatory diseases. Bergapten (BeG), a furocoumarin phytohormone present …
its regulation may result in a sustained inflammatory response and ultimately, local or systemic inflammation4. The inflammasome, a type of PRR, constitutes an essential component of the innate immunity5. Abnormal activation of inflammasomes is the pathogenesis of various inflammatory diseases6. The ...
Research progress in inflammasome NLRP3 and chronic inflammatory related diseases LIN Kai-ling, XUE Yan, YU Hui-zhen Key Laboratory of Geriatrics, Provincial Clinical Medical College of Fujian Medical University, Fuzhou 350001, China Abstract:
[Key words] Inflammatory bowel disease; Acupuncture-moxibustion therapy; Inflammasome; NLRP3 炎症性肠病(inflammatory bowel disease, IBD) 是一组影响胃肠道功能的慢性炎症性疾病,主要包括 克罗恩病(CD)和溃疡性结肠炎(UC)[1].其发病机制尚 未完全明确,可能与肠道上皮屏障功能的改变,肠道 微生物失调 , 肠道...