MicrogliaP2X7 receptorP2X7RGliomas are the most prevalent tumours of the central nervous system and present with high morbidity and mortality. The most common and most aggressive form of glioma is glioblastoma multiforme, of which patients have a median survival time of only 12 to 15 months. ...
Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21 Cell Rep., 28 (2019), 10.1016/j.celrep.2019.08.036 3105-3119.e7 Google Scholar [2] D. Hambardzumyan, D.H. Gutmann, H. Kettenmann The role of microglia and macrophages in glioma maintenanc...
Emerging Role of Tumor-associated Macrophages as Therapeutic Targets in Glioblastoma Multiforme. The most common types of primary brain tumors in adults are gliomas. Glioblastoma multiforme (GBM) is the most highly aggressive type of glioma. GBM contai... Xian-Bin,Lin,Guo-Han,... - 《Nano Biom...
These microglia-like cells will enable further studies into the role of microglia in health and disease. Hetal Pandya Michael J Shen John K Park Technical Report2 Mar 2017 Nature Neuroscience Chemically defined and growth-factor-free culture system for the expansion and derivation of human ...
Several decades of research have provided great insight into GBM progression; however, the prognosis remains poor, with a median patient survival time of ~15 months. The tumour microenvironment (TME) of GBM plays a crucial role in mediating tumour progression and thus is being explored as a ...
In the last few decades, the role of cancer stem cells in initiating tumors, metastasis, invasion, and resistance to therapies has been recognized as a potential target for tumor therapy. Understanding the mechanisms by which CSCs contribute to cancer pr
Glioblastoma (GBM) is an immunosuppressive, universally lethal cancer driven by glioblastoma stem cells (GSCs). The interplay between GSCs and immunosuppressive microglia plays crucial roles in promoting the malignant growth of GBM; however, t...
To better understand the evolution of the TME, the “seed and soil” theory was first proposed by Stephen Paget in 1863 to delineate the tropism of tumor metastases to specific organs [2]. Since then, increasing evidence has confirmed the essential role of the TME in tumorigenesis [1]. The...
in a decline of all the miRNAs that are normally highly expressed in these cells, and RNA-Seq shows that the gene with the greatest increase in the Dicer-CKOMGisBcan(encoding Brevican), a chondroitin sulfate proteoglycan29,30. Additional studies further support a role for Brevican and miR-9...
Proton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated proton...