Microglial–astroglial cell interactionsMicroglial activationMicroglia participates in most acute and chronic neuropathologies and its activation appears to involve interactions with neurons and other glial cells. Trimethyltin (TMT)-induced brain damage is a well-characterized model of neurodegeneration, in ...
old microglia die, and new microglia regenerate via self-renewal16,17,18,19,20,21. The generation of newly formed microglia is coupled with the apoptosis of dysfunctional microglia to maintain the stability of the cell population22. In the ...
a reduced microglial population and altered morphology. Although all glial cell types were reduced in cultures from irradiated spinal cords, the few microglia present were usually positioned atop astrocytes. The consistency of reduction in all glial populations in this model shows the microglia to be ...
3a, b) and, in distal microglia, these measures were decreased in male, compared with female, mice (§§§p < 0.001) indicating that cell complexity was reduced in males. Fig. 3: Evidence of sex-related differences in morphology of microglia distal from plaques. a 3D reconstructions ...
including the NOD-like receptor, TNF, chemokine, and mTOR signalling pathways, similar to those in the peripheral blood (Fig.5a). The IL-6 and Trp53 mRNA expression levels were also downregulated byA. muciniphilatreatment (Fig.5b, c). Microglia, as immune cells in the brain, are constant...
After a survival of 1 or 2 days (all age groups) or 4 days (young and middle-aged animals), immunohistochemically labeled astrocytes and microglia were investigated both qualitatively and quantitatively. In all age groups, astrocytes were markedly activated in periventricular as well as in deeper...
Microglia, the primary immune effector cells in the brain, continually monitor the tissue parenchyma for pathological alterations and become activated in A... Sungho,Lee,and,... - 《American Journal of Pathology》 被引量: 488发表: 2010年 Respiratory infection promotes T cell infiltration and amylo...
DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation Cross-talk between astrocytes and microglia plays an important role in neuroinflammation and central sensitization, but the manner in which glial cells int... Han, Jin,Cho, Hyun-Jung,Park, Donghwi,...
While TGF-β signaling is essential for microglial function, the cellular source of TGF-β1 ligand and its spatial regulation remains unclear in the adult CNS. Our data supports that microglia but not astrocytes or neurons are the primary producers of TG
microglia have also been observed in the context of demyelination mouse models and human iPS cell models9,10,11,12. It remains unclear whether the lipid-accumulating glial state originally described by A. Alzheimer in human AD brain tissue is influenced by lipid AD risk variants (for example,...