(1998) Macrophage and microglia-like cells in the avian inner ear. J. Comp. Neurol. 475: 241-256.Bhave SA,Oesterle EC,Coltrera MD.Macrophage and microglia-like cells in the avian inner ear. Journal of Comparative Neurology . 1998
A protocol is developed to enable the differentiation of microglial-like cells from human pluripotent stem cells, which are shown to resemble primary human microglia, integrate into 3D neuronal cultures, and perform phagocytic and injury-response functio
Once infected, however, microglia become immune competent serving as sources of cellular neurotoxic factors leading to disrupted brain homeostasis and neurodegeneration.Herein, we created a humanized bone-marrow chimera producing human "microglia like" cells in NOD.Cg-PrkdcscidIl2rgtm1SugTg(CMV-IL34)1...
Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: membrane currents. Glia 12, 259-267.Schmidtmayer J, Jacobsen C, Miksch G, Sievers J. 1994. Blood mono- cytes and spleen macrophages differentiate into microglia-like cells on monolayers of ...
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cellsCirculating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from their embryonic counterparts. As the ...
Protease sensitivity and nuclease resistance of the scrapie agent propagated in vitro in neuroblastoma cells. The scrapie agent has been propagated in vitro in mouse neuroblastoma cells. To further characterize the tissue culture-derived scrapie agent, we studied t......
Since microglia are difficult to procure from the human brain, several protocols have been developed to generate microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, some concerns remain over the purity and quality of in vitro generated microglia. Here, we describe a ...
Since microglia are difficult to procure from the human brain, several protocols have been developed to generate microglia-like cells from human induced pluripotent stem cells (hiPSCs). However, some concerns remain over the purity and quality of in vitro generated microglia. Here, we describe a ...
专利名称：DIFFERENTIATION AND USE OF HUMAN MICROGLIA-LIKE CELLS FROM PLURIPOTENT STEM CELLS AND HEMATOPOIETIC PROGENITORS 发明人：BLURTON-JONES, Mathew,ABUD,Edsel,POON, Wayne 申请号：EP18760945.8 申请日：20180226 公开号：EP3589293A1 公开日：20200108 专利内容由知识产权出版社提供 摘要：Disclosed herein...
Here, we measured the effect of CORT pretreatment on the downstream pro-inflammatory responses of BV2 mouse microglia-like cells stimulated by lipopolysaccharide (LPS). We quantified the concentration-dependent CORT-mediated attenuation and enhancement of LPS-stimulated inflammatory response. A high ...