我们描述了肿瘤异质性和与铁死亡敏感阈值相关的信号,并强调了临床应用的潜在治疗药物。 Oxidative damage in ferroptosis 铁积累和脂质过氧化是铁死亡过程中引发膜氧化损伤的两个关键信号。铁死亡的核心分子机制涉及调节氧化损伤和抗氧化防御之间的平衡。 Iron toxicity 与非恶性细胞相比,癌细胞(尤其是癌症干细胞)的生长强烈...
(2022) 22:266 https://doi.org/10.1186/s12935-022-02685-w Cancer Cell International REVIEW Open Access The role of ferroptosis in esophageal cancer Zimin Wang1,2†, Sikai Wu1,2†, Chengchu Zhu1,2* and Jianfei Shen1,2* Abstract Esophageal cancer is one of the...
The discovery of regulated cell death processes has enabled advances in cancer treatment. In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been implicated in the development and therapeutic responses of various types of tumours...
相比之下,参与HIPPO途径的转录因子(如YAP1和WWTR1(也称为TAZ,通常在发育过程中控制细胞数量和器官大小)的激活通过调节铁死亡调节剂(如ACSL4、TFRC、EMP1和ANGGPTL4)的表达促进癌细胞的铁死亡。总的来说,这些发现强调了理论上的使用铁死亡诱导药物特异性消除具有间充质样表型的癌细胞的可能性。未完待续……… 已...
Ferroptosis in cancer therapy Systemic therapy 传统的细胞毒性和靶向药物通过多种机制发挥作用,一般目的是通过诱导癌细胞死亡来减缓或阻止肿瘤生长,而不影响非转化细胞。然而,对靶向治疗的抵抗仍然是一个难以克服的挑战。越来越多的临床前证据表明,铁死亡的诱导可能是一种有用的治疗策略,可防止对几种癌症疗法的获得性...
FerroptosisIronLipid peroxidationEsophageal cancer is one of the most common cancers with high mortality rate around the world. Although the treatment strategy of this disease has made great progress, the prognosis of advanced patients is not ideal. Ferroptosis, a novel regulatory cell death model, ...
Broadening horizons_ the role of ferroptosis in cancer 下载积分: 500 内容提示: Most cancer treatment strategies are designed to selectively eliminate cancer cells without harming non- malignant cells. Distinct lethal subroutines of regulated cell death (RCD) processes differentially affect tumour ...
Furthermore, we delve into the complex role of ferroptosis within the tumor microenvironment and its interplay with antitumor immunity, offering insights into the prospect of targeting ferroptosis as a strategic approach in cancer therapy. 展开
The discovery of regulated cell death processes has enabled advances in cancer treatment. In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been implicated in the development and therapeutic responses of various types of tumours...
Will cancer cells have different ferroptosis tendency if they have different energy resource, either relying more on mitochondrial respiration or glycolysis? Introduction Regulated cell death, mainly including apoptosis, entosis, necroptosis, and pyroptosis, plays a critical role in maintaining homeostasis un...