Different gut microbial metabolites have the potential to promote and protect against colorectal cancer (CRC). A study now links trans-3-indoleacrylic acid (IDA), a metabolite derived from Peptostreptococcus anaerobius, with colorectal carcinogenesis through a distinct ferroptosis pathway AHR-ALDH1A3-...
Microbial regulation of ferroptosis in cancer Qiming Zhang Swagata Goswami Omer Yilmaz Nature Cell Biology News & Views 02 Jan 2024 Sections Figures References Abstract Data availability Code availability References Acknowledgements Author information Ethics declarations Peer review Additional information Exte...
VDAC2 is also a target of erastin, a small-molecule promotor of ferroptosis in cancer cells [76, 77]. However, interestingly, expression of SAT1 as well as SAT2 has been linked to improved outcomes in several adenocarcinomas [78,79,80,81]. We therefore evaluated the association of SAT1 ...
and resuspended in sterile PBS. The live or dead status of the tested bacteria of each group was observed with a flow cytometer after adding SYTO 9 and PI dyes of the LIVE/ DEAD BacLight Bacterial Viability Kit (Invitrogen) under the guidance of the manufacturer’s instructions. ...
This study aims to explore the prokaryotic microbial community structures and diversity in pit mud from different depths, and provide a theoretical basis for the liquor production and further study of pit mud. The fermented pit muds of strong-flavor liqu
Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. T-cell tolerance is an important mechanism for tumor escape, but the molecular pathways involved in T-cell tolerance remain poorly understood. It remains u....
A. Genomic analyses of a novel bacteriophage (VB_PmiS-Isfahan) within Siphoviridae family infecting Proteus mirabilis. Genomics 111, 1283–1291 (2019). Article CAS PubMed Google Scholar Tsay, J. J. et al. Airway microbiota is associated with upregulation of the PI3K pathway in lung cancer...
Gut microbiota regulation of P-glycoprotein in the intestinal epithelium in maintenance of homeostasis. Microbiome 2021, 9, 183. [Google Scholar] [CrossRef] Moriguchi, J.; Kato, R.; Nakagawa, M.; Hirotani, Y.; Ijiri, Y.; Tanaka, K. Effects of lipopolysaccharide on intestinal P-...
The excessive generation of ROS plays a pivotal role in the pathogenesis of many diseases [2]. Improper regulation of ROS levels contributes to the pathologies of many maladies including inflammation, cancer, and neurodegeneration [3,4,5]. Increased ROS production adversely affects the mitochondrial ...
Colorectal cancer (CRC) is the third most common cancer worldwide. The role of intestinal microbiota in carcinogenesis has also become an important research topic, and CRC is closely related to the intestinal microbiota. Selenium-containing compounds have attracted more attention as anticancer drugs as...