Cellular ferroptosis is recognised as a key mechanism by which certain chemotherapeutic agents induce cell death in cancer cells [65,69]. BC is a diverse tumour; based on the hormone receptors (ER and PR) and HER2 (ERBB2) signatures, BC is clinically classified into three main subtypes: TNBC...
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Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, ChinaBai, TingjieStraits Laboratory of Flexible Electronics (SLoFE), Straits Institute of Flexible Electronics (...
Iron and microbial infection. Nat Rev Microbiol. 2004;2:946–53. 21. Drakesmith H, Prentice A. Viral infection and iron metabolism. Nat Rev Microbiol. 2008;6:541–52. 22. Weinberg ED. Iron withholding: a defense against viral infections. Biometals. 1996;9:393–9. 23. Ganz T, Nemeth ...
Key Laboratory of Microbial Pathogenesis and Interventions of Fujian Province University, Biomedical Research Center of South China, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, China Yihang Ruan & Xuemei Zeng Contributions Ying Sun: Writing - original draft, Methodology,...
Until now, the mechanism of CD pathogenesis has not been fully understood. In this study, we revealed the involvement of ferroptosis in CD. We found that the key genes of ferroptosis were differentially expressed between CD patients and Non-IBD subjects both in PBMC and colonic biopsy specimens...
Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit their malignant biological behavior as a promising therapeutic approach. However, it is uncle...
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body’s immune system. This review provides an overview...
electron transport oxidative phosphorylation, nonalcoholic fatty liver disease, and metabolic pathways [102]. It has been found that GPX4 depletion-induced ferroptosis occurs in chronic obstructive pulmonary disease (COPD) pathogenesis under cigarette smoke exposure [103]. In addition, NCOA4 (nuclear rec...