A large number of studies have raised that ferroptosis might be a new option for clinical cancer therapy. However, it still exists long distance between the findings in the laboratory and the effective use in clinical cancer treatment using ferroptosis. Here, we introduced the main mechanism of ...
2022-02-24报道,近日,江苏省医院和南京医科大学第一附属医院的研究者在Molecular Cancer杂志上发表了题为“Ferroptosis in cancer therapy: a novel approach to reversing drug resistance”的综述性文章,在此,研究者对铁死亡的机制以及调节铁死亡在逆转肿瘤对化疗、靶向治疗和免疫治疗等常用治疗方法的耐药性方面的治疗作...
Ferroptosis in cancer therapy Systemic therapy 传统的细胞毒性和靶向药物通过多种机制发挥作用,一般目的是通过诱导癌细胞死亡来减缓...
biological functions, regulatory pathways, and interactions with the tumor microenvironment. We also summarize the potential applications of ferroptosis induction in immunotherapy, radiotherapy, and systemic therapy, as well as ferroptosis inhibition for cancer treatment in various conditions. We finally discus...
2022-02-24报道,近日,江苏省医院和南京医科大学第一附属医院的研究者在Molecular Cancer杂志上发表了题为“Ferroptosis in cancer therapy: a novel approach to reversing drug resistance”的综述性文章,在此,研究者对铁死亡的机制以及调节铁死亡在逆转肿瘤对化疗、靶向治疗和免疫治疗等常用治疗方法的耐药性方面的治疗作...
Cancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with each other to adapt to the complicated microenvironment. Ferroptosis is a regulated cell death induced by ir
Ferroptosis:An emerging therapeutic opportunity for cancer these ferroptosis-inducing agents,which include system Xcinhibitors,GPX4 inhibitors,and iron-based nanoparticles,in cancer therapy will be subsequently discussed... L Wang,X Chen,C Yan - 基因与疾病 被引量: 0发表: 2022年 Ferroptosis: An emerg...
In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death, such as apoptosis, and therefore holds great potential for cancer therapy....
We herein review the occurrence and regulation of ferroptosis in various cancer cells. The opportunity and challenge of cancer treatment based on ferroptosis will be detailed, which was desired to prosper new strategies for cancer therapy of clinical value. Ferroptosis, from a cancer perspective: an...
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to explore alternative cell death pathways. Ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal ...