Therefore, a new interdisciplinary subspecialty called "cardio-oncology" has emerged, aiming to detect and treat cardiovascular diseases associated with tumors and antitumor therapies. Recent studies have highlighted the role of ferroptosis in both cardiovascular and neoplastic diseases. The balance be...
BRCA1 and BRCA2 are crucial for the DNA damage repair [53,129]. They play an important role in the repair of double-strand breaks through homologous recombination (HR), activation of the cell cycle checkpoint and apoptosis [151,173,178]. Dysfunctional forms of BRCA genes are less capable t...
Lidocaine, a local anesthetic drug derived from cocaine, has also been demonstrated to affect the development of multiple tumors. For example, Sun et al.27 found that lidocaine induced the occurrence of ferroptosis in ovarian as well as breast cancer cells, which revealed the clinical value of ...
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in the regulation of numerous biological processes. Thus, substantial efforts have been made to understand the upstream signals that influence the activity of the Hippo pathway, as well as its physiological functi...
Ferroptosis defense mechanism of T cells Upon activation, CD4+and CD8+effector T cells require essential GPX4 to avoid ferroptotic cell death [27,39,40]. Interestingly, while system Xc−plays a significant role in other cell types, it appears less essential for the proliferation and immunologic...
Programmed death receptor-1 (PD-1) and its ligand, programmed death ligand-1 (PD-L1) are essential molecules that are key in modulating immune responses. PD-L1 is constitutively expressed on various immune cells, epithelial cells, and cancer cells, where
Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are involved in sever
Several pre-clinnical studies have suggested a better therapeutic role of CPCs-derived exosomes (CPCs-Ex) for cardiac repair compared with cell transplantation10. Indeed, CPCs-Ex containing specific agents have been effectively used to treat cardio-vascular disease. Chen et al.11 reported that Sc...
Therapeutic failure in prostate cancer (PC) is believed to result from its unusually invasive and metastatic nature. Cancer-associated fibroblasts (CAFs) are essential in the tumor microenvironment. We intended to study the role of CAF-derived exosomes i
Since reactive oxygen species (ROS) play a significant role in NET release, we aimed to investigate whether resveratrol (RSV), with a wide range of biological and pharmacological properties, could modulate NET release in response to different stimuli. Thus, human neutrophils were pretreated with ...