P. , Hamon M. , Lanfumey L. and Mongeau R. ( 2010 ) The role of 5-HT2C receptors in the antidepressant response: a critical review , in Psychopathology and Pharmacotherapy of Depression: Recent Advances and Future Needs ( CryanJ. F. and LeonardB. E. , eds), Karger, Basel....
The Role of the 5-HT6 Receptor in Compulsive Responding: an Investigation Using Viral Mediated Gene Transfer John Neumaier*, Daniel Eskenazi University of Washington, Seattle, WA Background: The 5-HT6 receptor has been implicated in reward and reinforcement learning, behaviors strongly influenced by...
et al., “Role of 5-HT2C receptors in the control of central dopamine function”, Trends in Pharmacological Sciences, vol. 22, No. 5, pp. 229-232 (2001).Di Matteo V, et al. Role of 5-HT2C receptors in the control of central dopamine function. Trends Pharmacol Sci. 2001;22(5):...
The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J Neurochem 79: 172–182. CAS PubMed Google Scholar Adrien J (2002). Neurobiological basis for the relation between sleep and depression. Sleep Med Rev 6: 341–352. Article PubMed ...
5-HT2A receptor function at the molecular levelIn the CNS, the 5-HT2A receptor is thought to be involved in learning, memory, and neurogenesis1 but its role in cognition is still not fully understood. In the CVS, the receptor is activated by 5-HT during wound healing and inflammation to...
Neurotrophins and other growth factors have been advanced as critical modulators of depressive behavior. Support for this model is based on analyses of knockout and transgenic mouse models, human genetic studies, and screens for gene products that are re
A body of evidence suggests there are alterations in the 5-HT2CR editing pattern in patients with certain neuropsychiatric diseases, and it has been suggested that 5-HT2CR RNA editing may play a role in anxiety and depression [21–25]. The aim of the current study was to evaluate the st...
Although the monoamine hypothesis of depression has mainly focused onnoradrenaline (NA) and serotonin (5-HT) as substrates of depression andantidepressant drug action, a role for the involvement of the mesotelencephalicdopamine (DA) syst... K Kõiv,K Raudkivi,A Alttoa,... 被引量: 0发表:...
Aromatic amino acids are important components of the ligand binding site in the Cys loop family of ligand-gated ion channels. To examine the role of tryptophan residues in the ligand binding domain of the 5-hydroxytryptamine(3) (5-HT(3)) receptor, we used site-directed mutagenesis to change...
SUMMARY In the light of recent pharmacological investigations using agonists and antagonists that have potent actions on 5-hydroxytryptamine-2 (5-HT 2 ) receptors, the possible functional role of 5-HT 2 receptors in the modulation of the sleep/wakefulness states was examined. Data obtained from an...