Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion channels (5-HT3) of the Cys loop fami...
Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. 2021 Apr;592(7854):469-473. 发布于 2024-04-29 13:19・IP 属地上海 生物化学 分子生物学 抑制剂 赞同1添加评论 分享喜欢收藏申请转载 ...
Within the past six months, isolation of cDNA or genomic clones has been reported for three 5-HT receptors, the 5-HT1C, 5-HT1A and 5-HT2 subtypes. As members of the G protein receptor superfamily, all three 5-HT receptor clones encode single-subunit proteins containing approximately 450 ...
[9] Cao L, Xu CB, Zhang Y, Cao YX, Edvinsson L (2013) Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5-HT(1) (B) receptors via the Raf/ERK/MAPK pathway in rats. Acta Physiol (Oxf) 207:183-193. [10] Nikolaienko O, Eriksen MS, Patil S, Bito H, Bramha...
6.Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsøe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE. Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. ...
HT2Creceptors (5-HT2CRs); the 5-HT2CR agonist lorcaserin was clinically used to treat human obesity [13]. Recent evidence indicates that lorcaserin not only inhibits food intake triggered by hunger [14,15], but also inhibits the consumption of high palatable foods in the absence of hunger ...
2022年6月16日,来自中科院上海药物研究所的徐华强团队,联合浙江大学张岩教授团队以及丹麦哥本哈根大学David E. Gloriam教授团队等,在《Molecular Cell》发表了题为“GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors”的最新的研究成果。这是研究人员首次报告...
《Molecular Cell》杂志上在线发表了他们的最新的研究成果GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors,取得了5-羟色胺受体结构和功能领域又一突破性进展,成功解析了5-HT4...
In this paper ,we review recent findings about the relationship between 5-HT receptors and anxiety disorder . 关键词:焦虑障碍、五-羟色胺受体 [Key Word]:Anxiety disorder、5-HT receptor 焦虑障碍是以焦虑综合征为临床表现的一组精神障碍。它是指一种持续性精神紧张或发作性惊恐状态。伴有头晕、胸闷、...
16,Peng YB, Lin Q, Willis WD. The role of 5-HT3 receptors in periaqueductal gray-induced inhibition of nociceptive dorsal horn neurons in rats. JPET, 1996, 276∶ 116~124. 17,Ghelardini C, Galeotti N, Casamenti F, et al. Central cholinergic antinociception induced by 5-HT4 agonists...