5-HT是一种抑制性神经递质，广泛存在于哺乳动物大脑皮层及神经突触中。SSRI是一类抗抑郁药品，主要是通过抑制突触前膜对5-HT的再摄取，从而起到抗抑郁的作用。而5-HT综合症的主要原因就是过多的游离5-HT直接激动5-HT受体，从而引起上述精神病症状[2]。5-HT受体是一群位于中枢神经系统和末梢神经系统周边的G蛋白...
Structural insights into the lipid and ligand regulation of serotonin receptors. Nature. 2021 Apr;592(7854):469-473. 发布于 2024-04-29 13:19・上海 生物化学 分子生物学 抑制剂 赞同2添加评论 分享喜欢收藏申请转载 ...
5-HTR, 5-HTR, and 5-HTR are three constitutively active G-coupled 5-HT receptors that have key roles in brain development, learning, memory, cognition, and other physiological processes in the central nervous system. In addition to Gsignaling cascade mediated by these three 5-HT receptors, ...
[9] Cao L, Xu CB, Zhang Y, Cao YX, Edvinsson L (2013) Secondhand cigarette smoke exposure causes upregulation of cerebrovascular 5-HT(1) (B) receptors via the Raf/ERK/MAPK pathway in rats. Acta Physiol (Oxf) 207:183-193. [10] Nikolaienko O, Eriksen MS, Patil S, Bito H, Bramha...
the determination of specific spatial populations of 5-HT receptors involved in mediating the beneficial effects of antidepressant treatment will yield a window into the neural circuitry that modulates mood-related behaviors. Therefore, we will also discuss the location of the 5-HT receptors that media...
Molecular biology of 5-HT receptors. Behav. Brain Res. 195, 198–213 (2008). Article CAS PubMed Google Scholar Hoyer, D. 5-HT receptor nomenclature: naming names, does it matter? A tribute to Maurice Rapport. ACS Chem. Neurosci. 8, 908–919 (2017). Article CAS PubMed Google ...
目前血清紧张素受体被归类为七个亚族(5-HT1至5-HT7)。参见,Hoyer,D.等人,“VII International Union of Pharmacology classification of receptorsfor 5-hydroxytrypt胺),Pharmacol.Rev.,56,157-203(1994)。亚族已经被进一步分成亚型。例如,5-HT2受体目前被分成三个亚型5-HT2a、5-HT2b和5-HT2c。5-HT2受体...
参考文献 Xiuli Zhao et al, Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3, Molecular Psychiatry (2022). DOI: 10.1038/s41380-021-01390-w
(0.5–4 M) whilst the other barrels contained pontamine sky blue dye and a combination of ligands for 5-HT and glutamate receptors. For the glutamate experiments PBG, AMPA and NMDA were always included in addition to one of the antagonists so that antagonist selectivity could be assessed. ...
In this study, we report the structure of Gi-coupled 5-HT5Acomplex bound to 5-CT at a resolution of 3.1 Å. This structure clarified the feature of 5-CT recognition by 5-HT5Aand identified a determinant for 5-CT affinities against Gi/o-coupled 5-HT receptors, thus providing a rati...