Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family which includes the monoamine receptors and a combination of ligand-gated ion channels (5-HT3) of the Cys loop fami...
2008. Molecular biology of 5-HT receptors. Behav Brain Res 195: 198-213.Hartig PR (1989) Molecular biology of 5-HT receptors. Trends Pharmacol Sci 10: 64-69Hartig P (1989) Molecular biology of 5-HT receptors. TIPS 10: 64-66Hartig PR. Molecular biology of 5-HT receptors. Trends ...
Molecular biology of 5-HT receptors. Receptors, SerotoninAmino Acid SequenceMolecular Sequence DataAuthor information: (1)Department of Pharmacology, Faculty of Medicine, University of Alberta, ... FG Boess,IL Martin - 《Neuropharmacology》 被引量: 2135发表: 1994年 Molecular biology of 5-HT recept...
(5-HT)receptorsareproteinsinvolvedinvariousneurologicalandbiologicalprocesses,suchasaggression,anxiety,appetite,cognition,learning,memory,mood,sleep,andthermoregulation.Theyarecommonlyassociatedwithdrugabuseandaddictionduetotheirimportanceastargetsforvariouspharmaceuticalandrecreationaldrugs.However,duetoahighsequencesimilarity/...
Newly endocytosed integral cell surface proteins are typically either directed for degradation or subjected to recycling back to the plasma membrane. The sorting of integral cell surface proteins, including signalling receptors, nutrient transporters, io
Hyperactivity of serotonin 3 receptors (5-HT3R) underlies pathologies associated with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a class of high-affinity competitive antagonists, are used in the treatment of these conditions. Although generally effective for chemothera...
Series:Methods In Molecular Biology>Book:Diagnosis of Sexually Transmitted Diseases Protocol|DOI:10.1007/978-1-61779-937-2_5 Affiliations: Department of Pathology, Milford Hospital, Milford, CT, USA Less Citations: 9 Access enabled via:An Institution ...
The volume of research delineating the role of death receptors (DRs) in prion disease remains remarkably limited. Available reports often present an incomplete picture, failing to comprehensively address the intricacies of all primary DRs, their cognate ligands, adaptor proteins, and critical post-trans...
Much of research and drug development in IBS patients has been based on descriptive and symptomatic features, rather than on biology-based disease definitions. These definitions suggest a core abnormality shared by all IBS patients (chronic, recurrent abdominal pain) as well as heterogeneity based on...
(Fig.4c). There did not appear to be a broader compensation in 5-HT signaling since there was no difference in the expression of other 5-HT receptor transcripts between genotypes (Fig.4c). Consistent with previous reports of the distribution of 5-HT receptors in the DG [29], the ...