Since these receptors co-express in various tissue and cell types and share the same ligand (5-HT), it has been a challenge for the researchers to define specific pathway and separate physiological role for each of these serotonin receptors. Though the evidence of operational diversity of these...
目的 观察 5 HT1A受体激动剂 8 OH DPAT和HT2受体拮抗剂利坦色林 (ritanserin)对大鼠清醒和睡眠成分的影响 ,给予 5 HT1A受体激动剂和剥夺REM睡眠后皮层 5 HT2 受体结合能力的变化 ,进一步分析两种 5 HT受体亚型之间的关系以及 5 HT2 受体在睡眠中的作用。方法 利用大鼠睡眠自动分析系统定量分析清醒和睡眠成分...
Functional characteristics of heterologously expressed 5-HT receptors. Over the past 10 years, molecular cloning has revealed the presence of 15 (; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except ... CC Gerhardt,HV Heerikhuizen - 《European Journal of Pharmacology...
Demonstration of 5-HT3 receptor function and expression in the mouse bladder The aim of this study was to demonstrate the presence of 5-HT3 receptors in the mouse bladder and to determine their location. Bladder strips from female m... N Chetty,IM Coupar,CWP Kerr - Naunyn-Schmiedeberg's ...
The pathophysiology of depression remains enigmatic, although abnormalities in serotonin signaling have been implicated. We have found that the serotonin 1B receptor [5-hydroxytryptamine (5-HT[sub 1B]) receptor] interacts with p11. p11 increases localization of 5-HT[sub 1B] receptors at the cell...
Role of 5-HT(2C) receptors in the control of central dopamine function [ab- stract]. Trends Pharmacol Sci 2001; 22: 229-32Di Matteo V, De Blasi A, Di Giulio C, Esposito E. Role of 5-HT(2C) receptors in the control of central dopamine function. Trends Pharmacol. Sci. 22(5), ...
Bourson A, Boess FG, Bo¨s M, Sleight AJ. Involvement of 5-HT6 receptors in nigro-striatal functions in rodents. Br J Pharmacol 1998;125:1562 - 6.Bourson A, Boess FG, Bos M, Sleight AJ (1998). Involvement of 5-HT6 receptors in nigro-striatal function in rodents. British Journal ...
In terms of sequence homology and pharmacology, these receptors are distinct and have differing distributions and function. In the last 5 years or so, the 5-HT 4 receptor has become the focus of much interest in both academia and the pharmaceutical industry. Elucidation of the role of the ...
Effect of 5-HT1B/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosetsEffect of 5-HT1B/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets5-HT 1B receptorsAgonist...
Define hypofunction. hypofunction synonyms, hypofunction pronunciation, hypofunction translation, English dictionary definition of hypofunction. hypofunction. Translations. English: hy·po·func·tion n. hipofunción, deficiencia en el funcionamiento de