C McCreary A, Newman-Tancredi A. Serotonin 5-HT1A receptors and antipsychotics-an update in light of new concepts and drugs[J]. Current pharmaceutical design, 2015, 21(26): 3725-3731. 当今制药,涵盖了目前药物设计各个方面的研究,包括药物化学、药理学...
C McCreary A, Newman-Tancredi A. Serotonin 5-HT1A receptors and antipsychotics-an update in light of new concepts and drugs[J]. Current pharmaceutical design, 2015, 21(26): 3725-3731. 当今制药,涵盖了目前药物设计各个方面的研究,包括药物化学、药理学、药物靶标和疾病机制。ISSN:1381-6128,IF 3.0...
The effect and clinical significance of 5-HT1A receptors. Sichuan Mental Health, 2006, 19(3):188-191. (in Chinese)李冠军,王慧芳,李华芳. 5-HT 1A受体的作用及其临床意义[J].四川精神卫生,2006,(03):188-191.doi:10.3969/j.issn.1007-3256.2006.03.035.李冠军,工慧芳,李华芳. 5-HT_(1A)受体的...
Ye N, Song Z, Zhang A. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents[J]. Current medicinal chemistry, 2014, 21(4): 437-457. 当代药物化学,涵盖了药物化学和合理药物设计的最新和最突出研究。ISSN:0929-8673,IF3.455 大话精神编...
BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human 5-HT1A receptors. 照片描述: IHC image of neurons staining for the 5-HT1A receptor in the rat cortex (above) and 5HT1A receptor staining of astrocytes in the rat hippocampus (below). The...
Ye N, Song Z, Zhang A. Dual ligands targeting dopamine D2 and serotonin 5-HT1A receptors as new antipsychotical or anti-Parkinsonian agents[J]. Current medicinal chemistry, 2014, 21(4): 437-457. 当代药物化学,涵盖了药物化学和合理药物设计的最新和最突出研究。ISSN:0929-8673,IF3.455 ...
Role of 5-HT1A receptors in depression and anxiety Several recent studies further imply diminished 5-HT1A-receptor action in depression and anxiety. Reduced 5-HT1A activity results in inhibition of the superficial cells of the entorhinal cortex (EC), the main input to the hippocampus. Activation ...
5-HT1A receptors are of special interest, since there are data on their involvement in the mechanisms of sleep[6] and hypothermia[7]. The results so far show that the 5-HT1A receptor has an important role in modulating the serotonergic effects on sleep / wake cycle and body temperature[8,...
正常人脑部5-HT1A受体PET显像方法学探讨及正常分布研究(2复旦大学附属华山医院上海200040)【摘要】目的:本研究主要通过分析5-HT1A受体PET显像剂18F-MPPF在健康人脑部的正常分布,摸索合适的图像分析方法,建立人体中枢神经系统5-HT1A受体PET显像的方法学。方法:使用18F-MPPF对9例正常人进行脑部5-HT1A受体显像,利用感兴趣...
摘要:5-HT1A脑受体作为人体的内源性活性物质,与体内很多生理病理状态密切相关。目前已有多种核素用于标记5-HT1A受体,本文将对放射性核素标记的5-HT1A脑受体显像剂研究进展做一综述。关键词:5-HT1A受体;99mTc;18F;显像剂 1. 引言 5-羟色胺(5-hydroxytryptamine,5-HT)又名血清素,最早是从血清中提取出来...