Thus, this well-known fibrogenic cytokine is important both for the emergence of the myofibroblast and its survival against apoptotic stimuli. This is consistent with the critical importance of this cytokine in diverse models of fibrosis in various tissues. In view of these properties, the ...
Molecular Targets in Pulmonary Fibrosis * Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 2007; 132:1311-1321.Scotton, C. J. & Chambers, R. C. Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest. 132, 1311-1321 (2007)... CJ Scotton,RC Cham...
Its role in myofibroblast differentiation is, however, unknown. We studied the expression and the localization of SRF in bleomycin-induced pulmonary fibrosis,... Y Yaniv,A Landesberg,R Sivan - 《Am J Respir Cell Mol Biol》 被引量: 107发表: 2003年 Glycolytic Reprogramming in Myofibroblast Differe...
The interaction of PD1 expressed in T cells with PD-L1 on cancer cells suppresses the proliferation and survival of T cells, which ultimately leads to immunosuppression. Pembrolizumab and nivolumab are ICIs that target PD1 to prevent PD1/PD-L1 interaction [19]. In contrast, atezolizumab and durva...
Subretinal fibrosis remains a major obstacle to the management of neovascular age-related macular degeneration. Choroidal pericytes were found to be a significant source of subretinal fibrosis, but the underlying mechanisms of pericyte-myofibroblast tran
(S100A6) being expressed in all of them. Indeed, HS appear to be the main source of myofibroblast-like cells following most injuries, having a central role in hepatic fibrosis and the underlying imbalance between ECM synthesis and degradation82. Portal myofibroblasts also play a part in liver ...
This change was parallel with a decrease in the expression of K-smooth muscle actin protein, a marker for myofibroblast, as determined by immuno- blot analysis. Northern blot analysis showed that IFN-Q inhibited proK2(I) collagen mRNA expression that was stimulated by TGF-L1 pretreatment for ...
mediated myofibroblast contraction as a potential checkpoint in the progression of fibrosis, restricting autocrine generation of myofibroblasts to a stiffened ECM... PJ Wipff,DB Rifkin,Jean-Jacques Meister and Boris Hinz - 《Journal of Cell Biology》 被引量: 1522发表: 2007年 Characterisation of corn...
(SLC7A11) in human leukemia32. lncRNA ZFAS1 knockdown attenuates ferroptosis by sponging miR-150-5p to downregulateSLC38A1expression in pulmonary fibrosis29. Since Nrf2 inhibits iron absorption, limits ROS production and up-regulates the expression ofSLC7A11, miRNA can affect ferroptosis by ...
Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathwayThe goals of this study were to investigate the role of the Notch1/PDGFRβ/ROCK1 signaling pathway in the pathogenesis of pulmonary fibrosis and to explore the possibility of ...