The primary function of fibroblasts is to produce structural proteins that comprise the extracellular matrix (ECM). This can be a constructive process; however, hyperactivity of cardiac fibroblasts can result in excess production and deposition of ECM proteins in the myocardium, known as fibrosis, ...
Cardiac fibroblasts in the neonatal and adult heart harbor a primary cilium. This organelle and its requisite signaling protein, PC1, are required for critical elements of fibrogenesis, including TGF-β1 SMAD3 activation, production of extracellular matrix proteins, and cell contractility. Together, ...
Activation of endogenous TGF-βis observed during the development of cardiac fibrosis in response to MI. To determine the effects of ZYZ-168 on myofibroblasts differentiation, cardiac fibroblasts were isolated from the healthy left ventricular tissues of adult animals and stimulated with 500 nM ...
Of these, fibrosis is the least understood. Following MI, activated cardiac fibroblasts (CFs) deposit extracellular matrix. Current therapies to prevent fibrosis are inadequate and new molecular targets are needed. METHODS AND RESULTS:-Herein we report that GSK-3β is phosphorylated (inhibited) in ...
Epicardium-derived fibroblasts in heart development and disease MingFang, ...Katherine E.Yutzey, inJournal of Molecular and Cellular Cardiology, 2016 1Introduction Cardiac fibrosisoccurs in the context of multiple cardiac stresses including myocardial infarction (MI), hypertensive heart disease (HHD), ...
Cardiac fibroblasts are responsible for (physiological and pathological) ECM synthesis in the heart muscle and play an important role for the structural, mechanical and electrical cardiac function [[26], [27], [28]]. 4. Cardiac fibrosis Cardiac fibrosis is a scarring event in the cardiac ...
Wound healing, cardiac fibrosis, and infarct scar development, while possessing distinct features, share a number of key functional similarities, including extracellular matrix synthesis and remodeling by fibroblasts and myofibroblasts. Understanding the underlying mechanisms that are common to these processes...
Cardiac fibroblasts comprise an essential cell type in the heart that is responsible for the homeostasis of the extracellular matrix; however, upon injury, these cells transform to a myofibroblast phenotype and contribute to cardiac fibrosis. This remodeling involves pathological changes that include ...
In response to stress, the heart undergoes extensive cardiac remodeling that results in cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to heart failure. Alterations in microRNA (miRNA) levels are associated with dysfunctional gene expression profiles associated wit...
Cardiac fibroblasts play a central role in the maintenance of extracellular matrix in the normal heart and as mediators of inflammatory and fibrotic myocardial remodeling in the injured and failing heart. In this review, we evaluate the ... RD Brown,SK Ambler,MD Mitchell,... - 《Fibrosis Myoca...