(HealthDay) -- Cells that normally form scar tissue after a heart attack can be reprogrammed into functional heart cells in mice, according to an experimental study published online April 18 inNature. Noting that cardiac fibroblasts can be reprogrammed in vitro to become adult cardiomyocyte-like c...
1.Either inadequate or excessive accumulation of fibroblasts could result in abnormal tissue function. 纤维细胞积聚不足或者过多都能导致组织功能异常。 2.MethodsThe human keloid fibroblasts were cultured in vitro. 成纤维细胞是瘢痕形成的效应细胞,是研究的重点。
Bobryshev, The role of cardiac fibroblasts in post-myocardial heart tissue repair. Exp Mol Pathol, 2016. 101(2): p. 231-240.The role of cardiac fibroblasts in post-myocardial heart tissue repair. Chistiakov D A,Orekhov A N,Bobryshev Y V. Experimental and Molecular Pathology . 2016...
Cell communication is needed for organ function and stress responses, especially in the heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the major cell types in the ventricular myocardium that together coordinate all functional processes. Critical to this cellular netw...
Fibroblasts also have central roles in pathogenic remodelling during myocardial ischaemia, hypertension and heart failure. As key contributors to scar formation, they are crucial for tissue repair after interventions including surgery and ablation. Novel experimental approaches targeting cardiac fibroblasts are...
TGF-β1, upregulated in keloid tissue, promotes the proliferation, collagen formation and differentiation of dermal fibroblasts. miR-21 is one of microRNAs first found in human genome. The aim of our study is to explore the mechanisms of miR-21 in TGF-β1-induced scar fibroblasts proliferation...
issued patents issued/pending across a variety of clinical pathways, including Disc Degeneration, Multiple Sclerosis, Parkinson’s, Chronic Traumatic Encephalopathy, Colitis, Cancer, Diabetes, Liver Failure and Heart Failure. FibroGenesis represents the next generation of medical advancement in cell therapy...
It is widely accepted that CAFs are a heterogeneous cell type and that this diversity may arise from their cell (s) of origin, the tissue in which they develop, or their activation state at any given time. This heterogeneity has presented challenges to precisely and exclusively identifying CAFs...
Heart fibroblasts also express Csf1, Vegfa, Igf1 and Fgf2, indicating active paracrine signaling to other cell types in the heart69. The human adult heart was found to contain seven fibroblast subtypes, two of which show enrichment in atria and ventricles and can be distinguished by expression...
fibroblasts are able to secrete growth factors and mitogens and produce structural components of ECM to restore normal tissue architecture14,15. Even in a non-regenerative organ like the heart, where fibroblast activity is mainly associated to fibrosis and organ dysfunction, neonatal fibroblasts and ...