Fibroblasts in the heart can respond to mechanical deformation of the plasma membrane with characteristic changes of their membrane potential. Membrane depolarization of the fibroblasts occurs during the myocardial contractions and is caused by an influx of cations, mainly of sodium ions, into the ...
Cell communication is needed for organ function and stress responses, especially in the heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the major cell types in the ventricular myocardium that together coordinate all functional processes. Critical to this cellular netw...
Cell communication is needed for organ function and stress responses, especially in the heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the major cell types in the ventricular myocardium that together coordinate all functional processes. Critical to this cellular netw...
C. et al. Organization of fibroblasts in the heart. Dev. Dyn. 230, 787–794 (2004). Article CAS PubMed Google Scholar Ramirez-Montagut, T. et al. FAPα, a surface peptidase expressed during wound healing, is a tumor suppressor. Oncogene 23, 5435–5446 (2004). Article CAS PubMed ...
(HealthDay) -- Cells that normally form scar tissue after a heart attack can be reprogrammed into functional heart cells in mice, according to an experimental study published online April 18 in Nature.
stability of the synchronization of two cardiomyocytes connected by a fibroblast, analyzed the contributions of cardiac fibroblasts to the synchronization of cardiomyocyte beating, and discussed the effect of the fibroblast population in heart tissue on the 'community effect' of cardiomyocyte network ...
Heterogeneous cell coupling in the heart: an electrophysiological role for fibroblasts. Peter,Kohl - 《Circulation Research》 被引量: 179发表: 2003年 Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts Transplantation studies in mice and rats have shown ...
TCs have previously been identified in different anatomic structures of the heart, and have also been isolated and cultured from heart tissues in vitro. TCs and fibroblasts, both located in the interstitial spaces of the heart, have different morphologies and functionality. However, other than ...
Signaling mechanisms regulating fibroblast activation, phenoconversion and fibrosis in the heart. Indian J Biochem Biophys 2014; 51: 476–482. CAS PubMed Google Scholar Xia H, Nho RS, Kahm J, Kleidon J, Henke CA . Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in ...
The other steady state has zero cell types. Such bistability was recently exploited therapeutically in the context of abrogating fibrosis in mice models in the heart39 and liver40. The complete dynamical mapping of the circuit in co-culture, known as a phase portrait, allows one to infer the...