Type V intermediate filaments are lamins, or fibrous proteins found in a cell's nucleus. Unlike the other types, which are all considered cytoskeletal, Type V filaments are nucleoskeletal — the lamins form a mesh within the inner membranes that surround the nucleus. Lamins are involved in seve...
aAng II induces the synthesis and secretion of fibronectin and collagen types I and III from cardiac fibroblasts and accelerates cardiac fibrosis in the noninfarcted myocardium, which is considered to be a major reason for the development of chronic heart failure in diabetes。 Ang II导致综合,并且...
We lost my aunt to cardiac fibrosis and cardiovascular diseases run in the family. Should I be worried about my risk of developing myocardial fibrosis? Is there anything genetic about this condition? And have any other risk factors been proven to cause myocardial fibrosis other than malaria, infl...
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest 2010; 120: 254–65. 163 Vivar R, Humeres C, Varela M, Ayala P, Guzman N, Olmedo I, et al. Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-...
Neighboring cardiac muscle cells in the walls of heart chambers have specialized cell-cell contacts that electrically and mechanically link the cells together, permitting the immediate passage of muscle impulses. What are these cell-cell contacts called? What are the cells that produce connective tissue...
Why are some amyloidoses systemic? Does hepatic "chaperoning at a distance" prevent cardiac deposition in a transgenic model of human senile systemic (tran... In the human systemic amyloidoses caused by mutant or wild-type transthyretin (TTR), deposition occurs at a distance from the site of ...
Cardiac fibroblasts Cardiomyocyte hypertrophy Antagonism in hypertrophy Bang et al. (57), 2014 Cardiosphere-derived cells EV blockade prevents, and EVs mimic, CDC benefits Myocardial infarction, heart failure Ibrahim et al. (19), 2014 c-kit+ heart cells Enhanced endothelial cell tube formation, decr...
Besides mouse and rat, cultured adult rabbit CMs also undergo dedifferentiation, which is further enhanced in the presence of cardiac fibroblasts [97]. Nevertheless, the restrictions of this model are also obvious. There may be contamination of non-myocytes in the culture, whose secretomes may ...
Effects of mibefradil on intracellular Ca2+ release in cultured rat cardiac fibroblasts and human platelets Naunyn Schmiedebergs Arch Pharmacol, 353 (1995), pp. 94-101 Google Scholar 170. W. Huang, C. Lu, Y. Wu, S. Ouyang, Y. Chen T-type calcium channel antagonists, mibefradil and NNC-...
Fourth, future strategies are needed to address the issue of poor engraftment and survival of these cells after transplantation, as with adult stem cells. Finally, other than the potential application of iPSCs for cardiac regeneration, they have been proposed as an in vitro platform for specific ...