The lung fibroblasts of the knockout heterologous fumarate hydratase gene rat can immortal in vitrodoi:10.1016/j.omto.2022.02.005Zhirui FanYuanyuan ZhengXiaoli LiXiaoming DengYan BaKun FengJin SuHui WangZhenhe SuoLifeng LiElsevier
ZIP1+ fibroblasts are enriched in mouse lung cancer after chemotherapy We aimed to study the early-stage adaptation of CAFs to chemotherapy-induced damage. Considering that lung cancer patients receiving chemotherapy are usually at advanced stages with distant metastases, the ectopic tumour model might...
Non-small cell lung cancer (NSCLC) patients with idiopathic pulmonary fibrosis (IPF) show poor prognosis. Periostin is an extracellular matrix protein highly expressed in the lung tissues of IPF. This study aimed to investigate the possibility that periostin secreted by fibroblasts derived from IPF ...
The present invention discloses novel methods and omental, myocardial, liver, lung, renal, peritoneal, intestinal and pancreatic mesothelial cells which are useful for a number of procedures including drug discovery, co-culturing, cell t... BENJAMIN MARCUS BUEHRER,RICHARD BENTLEY CHEATHAM,JAMES BRADFOR...
GPCRs are important targets for pharmaceuticals and the rat is one of the most widely used model organisms in biological research. Accurate... DE Gloriam,R Fredriksson,HB Schith - 《Bmc Genomics》 被引量: 301发表: 2007年 The human and mouse repertoire of the adhesion family of G-protein-...
Smoking is known to be linked to skin ageing and there is evidence for premature senescence of parenchymal lung fibroblasts in emphysema. To reveal whether the emphysema-related changes in cellular phenotype extend beyond the lung, we compared the proliferation characteristics of lung and skin fibrobla...
Lung fibroblasts have been shown to play a key role in lung inflammatory responses. However, their exact role in initiation and maintenance of lung diseases has remained elusive partly due to the limited availability of physiologically relevant in vitro models. Therefore, developing new tools that ...
The accumulation of collagen within the lung interstitium leads to impaired respiratory function. Furthermore, smooth muscle actin-positive myofibroblasts within the fibrotic lung contribute to disease progression. Because collagen and smooth muscle cell α-actin are coordinately expressed in the setting of...
Lung fibroblasts play a pivotal role in pulmonary fibrosis, a devastating lung disease, by producing extracellular matrix. MicroRNAs (miRNAs) suppress numerous genes post-transcriptionally; however, the roles of miRNAs in activated fibroblasts in fibroti
Here we find that proline, a highly abundant amino acid in collagen proteins, is newly synthesized from glutamine in CAFs to make tumour collagen in breast cancer xenografts. PYCR1 is a key enzyme for proline synthesis and highly expressed in the stroma of breast cancer patients and in CAFs...