, the 91-R strain represents a unique model (due to its high resistance to DDT, well established resistance mechanisms, and many “omics” tools) for understanding the interplay between xenobiotic stress, energy metabolism, and longevity within the context of the insulin signaling pathway....
The insulin signaling pathway. J. Membr. Biol . 1999;169:1–12.Taha C, Klip A. The insulin signaling pathway. J Membr Biol. 1999; 169 :1–12. [ PubMed ]Taha C, Klip A (1999) The insulin signaling pathway. J Membr Biol 169(1):1–12...
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway Tambascia RC et al (2005) Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. ... M Ueno,JBC ...
OGT‐1 regulates synaptic assembly through the insulin signaling pathway The formation and maintenance of synapses are precisely regulated, and the misregulation often leads to neurodevelopmental or neurodegenerative disorders. ... M Wu,H Jiang,LZ Shao - 《Journal of Cellular Biochemistry》 被引量: 0...
Findings from non-clinical studies suggest that AJD101 stimulates insulin independent glucose uptake by directly activating the insulin signaling pathway. Ajinomoto, Sankyo in Joint Development, Manufacture and Marketing of AJD101, New Diabetes Drug More results ► Encyclopedia browser ? ▲ signal resh...
The insulin/insulin-like signaling pathway (IIS) has been shown to mediate life history trade-offs in mammalian model organisms, but the function of this pathway in wild and non-mammalian organisms is understudied. Populations of western terrestrial garter snakes (Thamnophis elegans) around Eagle Lak...
associated with the insulin signaling pathway, TNF signaling pathway, and AMPK signaling pathway. Molecular docking results and molecular dynamics simulation showed that most ginsenosides could stably bind to the core target, mainly hydrogen bonding and hydrophobic bond. This study suggests the management...
Comparative tranome profiling reveals that adenoma-like islet tumors are most similar to immature but differentiated insulin-producing β cells, whereas the invasive carcinomas are most similar to embryonic islet cell precursors. The progression toward poorly differentiated carcinomas involves a first step...
Endosomes help activate the hepatic insulin-evoked Akt signaling pathway, but the underlying regulatory mechanisms are unclear. Previous studies have suggested that the endosome-located protein WD repeat and FYVE domain–containing 2 (WDFY2) might be involved in metabolic disorders, such as diabetes....
PKB/Akt is known to play an important role in the insulin signaling pathway leading to glucose transport and glycogen synthesis. We therefore examined insulin-induced PKB/Akt phosphorylation in cells expressing WT and NLS-mutated human IR. Results are shown in Fig. 6. In cells overexpressing WT...