Lizcano JM, Alessi DR. The insulin signalling pathway . Curr Biol (2002) 12 ( 7 ):R236–810.1016/S0960-9822(02)00777-7 [ Cross Ref ]Lizcano JM, Alessi DR. The insulin signaling pathway. Curr Biol. 2002; 12 :236–238.Lizcano JM, Alessi DR. The insulin signalling pathway. Curr Biol...
The development of insulin resistance and type 2 diabetes is determined by various factors, including defects within the insulin signaling pathway. Mediators of insulin resistance operate through activation of various protein kinase C (PKC) isoforms, IκB kinase β (IKKβ...
Findings from non-clinical studies suggest that AJD101 stimulates insulin independent glucose uptake by directly activating the insulin signaling pathway. Ajinomoto, Sankyo in Joint Development, Manufacture and Marketing of AJD101, New Diabetes Drug More results ► Encyclopedia browser ? ▲ signal resh...
L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131, 3897–3906 (2004). CAS PubMed Google Scholar Kapahi, P. et al. Regulation of lifespan in Drosophila by modulation of genes in the TOR ...
Insulin is a protein hormone that controls the metabolism of sugar, fat and protein via signal transduction in cells, influencing growth and developmental processes such as reproduction and ageing. From nematodes to fruit flies, rodents and other animals
[134]. Akt1 inhibits apoptosis and improves cell survival [135]. Akt2 is involved in the insulin signaling pathway [136] as evidenced by the development of IR and T2DM-like symptoms in human with an Akt2 deficiency [137]. Although there are reviews that describe the role of Akt in ...
Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin. 来自 Semantic Scholar 喜欢 0 阅读量: 32 作者:Mechin,M.-C.摘要: Incubation of isolated rat cardiomyocytes with insulin increased 2-deoxyglucose uptake, glycogen synthesis, and fructose 2, 6-bisphosphate ...
The MAPK pathway is responsible for leptin-induced c-fos activation [49]. It is of note that in LRlo signal transduction SOCS3 may also function as an adapter protein to other pathways [50]. Mice lacking PTP1B (phosphotyrosine phosphatase 1B) are hypersensitive to insulin and leptin and ...
The IGF1/insulin signaling pathway is a very well recognized target in postponing ageing. In mammals upstream of IGF1 is a growth hormone (GH) (Brown-Borg and Bartke2012). GH mutant mice (a reduction of plasma levels or disruption of the receptor) live 50% longer than wild-type ones. ...
The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http:... White,F Morris - 《Science》 被引量: 763发表: 2003年 Signaling via the insulin-like growth factor-I receptor: Does it differ fro...