were highly expressed in WMs and WFs workers, whilemTORexpression was lower in PKs and PQs than in WMs and WFs. PQs and PKs exhibited lower expression ofakt2-athan female workers. As the highly conserved insulin signalling pathway can significantly prolong the healthspan and lifespan, so we i...
Pathway analysis of the top 100 dmCpG-associated genes after adjustment for BMI showed enrichment of regulation of epidermal growth factor receptor (FDR 1.01 × 10−02) and regulation of protein kinase B signalling (FDR 1.89 × 10−02) and anatomical structure morphogenesis (FDR ...
This disruption is notable in the PI3K/Akt/GLUT4 pathway, crucial for glucose uptake and metabolism in skeletal muscle and adipose tissues, highlighting the pathway’s central role in maintaining insulin sensitivity [43]. Beyond the signaling pathways, the metabolic dimension of IR involves crucial ...
An insulin-like signaling (ILS) pathway has profound effects on C. elegans development, fertility, stress resistance, metabolism and life span. Hypomorphic mutations in the gene encoding the insulin receptor-like protein, DAF-2, increase worm life span by 100% and affect various developmental and...
Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been extensively studied. Upon insulin binding, the insulin receptor (IR) triggers
Role of insulin-induced reactive oxygen species in the insulin signaling pathway Antioxid Redox Signal, 7 (2005), pp. 1021-1031 Google Scholar [70] A. Espinosa, A. García, S. Härtel, C. Hidalgo, E. Jaimovich NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in...
These findings suggest that autonomous IGF2-IR signaling activation in NB-exposed AT2s leads to the development of emphysema. Fig. 4 Attenuation of NB-induced emphysematous features by Insr knockout in type II alveolar epithelial cells. A Schematic diagram of the experimental procedure. B ...
For example, diminished IR and insulin like growth factor receptor (IGFR) gene levels were reported in AD post mortem brain tissue (Steen et al., 2005), and impaired response to insulin-induced activation of the insulin receptor substrate-1 (IRS-1) signaling pathway was detected in cortex ...
Generation of cAD-MSC-derived IPCs by microenvironment manipulation. Diagram of culture technique used for the generation of cAD-MSC-derived IPCs is shown in (A). Morphological appearances of cells that underwent induction technique were observed under phase-contrast microscope with magnification of 40...
“Notch inhibitor” refers to an inhibitor of the Notch signaling pathway. “Ngn3” refers to Neurogenin-3, a protein expressed in endocrine progenitor cells and associated with enteroendocrine differentiation. “Ngn3 Assay” as used herein is an assay used to determine the extent of expression of...