Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1. PI-3Kinase Pathway: Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, MTOR, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, ...
Insulin_Receptor_Pathway之经典信号通路.ppt,P P P P P P P P P Glycogen Synthase c-Jun EEF2K eIF4 EEF2 Translation Anti-apoptosis Gene Expression Translation Fatty Acid Synthesis ATP Citrate lyase Glucose EBS Gene Expression P P p70S6K JNK eIF4EBP Insulin
SMPDL3b regulates the insulin-signaling pathway in human podocytes. a Representative Western blot image of main downstream targets of the insulin receptor signaling in control (CTRL), SMPDL3b knockdown (siSMP) and SMPDL3b overexpressing (SMP OE) podocytes exposed to increasing concentration of insul...
Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR (2013) Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. J Biol Chem 288:23807–23813 (Epub ahead of print)Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve...
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2, 887–893 (1998). Article CAS PubMed Google Scholar Song, M. S., Salmena, L. & Pandolfi, P. P. The functions and regulation of the PTEN tumour suppressor. Nat. Rev....
The process of insulin signaling begins through the binding of two insulin molecules, one to each of the two α subunits of the receptor. This results in a conformational change in the α subunits which is detected by the two intracellular insulin receptor β subunits. (B) Summary of the ...
Insulin signaling controls cell growth and metabolic homeostasis. Dysregulation of this pathway causes metabolic diseases such as diabetes. Insulin signaling pathways have been extensively studied. Upon insulin binding, the insulin receptor (IR) triggers
1.PI3K, its downstream target,protein kinase B(PKB/Akt),and insulin receptor play important roles in insulin signaling pathway together, and they areinvolved in insulin stimulated glucose transport and GLUT-4 transfer.它以及它下游的靶目标和胰岛素受体底物(IRS1,2)一起在胰岛素信号转导通路中发挥重要...
To test the idea that insulin receptor signaling regulates the formation of brain circuits during development, the Cold Spring Harbor team used two different techniques to block the function of the receptor in neurons located in the visual pathway of tadpoles. One method "knocked down" expression ...
3) Insulin signaling pathway 胰岛素信号转导通路 1. PI3K, its downstream target,protein kinase B(PKB/Akt),and insulin receptor play important roles in insulin signaling pathway together, and they areinvolved in insulin stimulated glucose transport and GLUT-4 transfer. 它以及它下游的靶目标和...