To elucidate the effects of dietary fatty acid composition on the insulin signaling pathway, we measured the gene expression of the earliest steps in the insulin action pathway in skeletal muscle of rats fed a safflower oil diet or a beef tallow diet. Rats were meal-fed an isoenergetic diet ...
Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skelet... Aims/hypothesis: Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent...
tional pathway steps elucidated and characterized since the publication of Sedaghat's model. All signaling steps used in Sedaghat's model are included in our expanded model. To improve the level of uncertainty in Sedaghat's model, we have added steps downstream of PKC/AKT components crucial for ...
The positive and negative modulators acting on different steps of the signaling pathway, as well as the diversity of protein isoform interaction, ensure a proper and coordinated biological response to insulin in different tissues. Whereas genetic mutations are causes of rare and severe insulin ...
The finding that insulin-stimulated PI 3-kinase activity increased after trauma in both Wistar and GK rats indicates that postoperative insulin resistance is not caused by an impairment in the early steps of the insulin signaling pathway. The postoperative decreases in serum insulin despite high ...
et al. GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps. Mol. Biol. Cell 13, 2421–2435 (2002). CAS PubMed PubMed Central Google Scholar Xu, Y. et al. Dual-mode of insulin action controls GLUT4 vesicle exocytosis. J. Cell Biol. 193, 643–653 ...
Although many of the proximal steps in insulin signaling have been identified, the molecular mechanisms underlying insulin resistance under various metabolic states are still unclear. Recent study suggests that Rho-kinase is an important mediator of insulin signaling and glucose homeostasis. Specifically, ...
4b). These data suggest that simvastatin may inhibit insulin mediated glucose uptake by blocking a critical steps in insulin signaling cascade. Figure 4 (a) Simvastatin treatment inhibits insulin signaling cascade: L6 myotubes were cultured in Simvastatin for 48 h, followed by stimulation with ...
Thus, OGT attenuates insulin signal by O-GlcNAcylation of proteins involved in proximal and distal steps in the PI-3 kinase signaling pathway. This negative feedback may be exacerbated when cells are chronically exposed to elevated glucose concentrations and could thereby contribute to alterations in ...
FORUM ORIGINAL RESEARCH COMMUNICATIONInsulin Signaling and Insulin Sensitizing in Muscle and Liverof Obese Monkeys: Peroxisome Proliferator-ActivatedReceptor Gamma Agonist Improves Defective Activationof Atypical Protein Kinase CHeidi K. Ortmeyer,1–3Mini P. Sajan,4,5Atsushi Miura,6Yoshinore Kanoh,6Jose ...