Fig. 2.Schematic diagram of insulin signaling pathways that affect synaptic remodeling and glucose transport. The insulin receptor tyrosine kinase (RTK) phosphorylates insulin receptor substrates (IRS), activating the Ras/Raf pathway through a series of protein interactions involving Grb2, son...
Background: The insulin/insulin-like signalling (IIS) pathway is common in mammals and invertebrates, and the IIS pathway is unknown in Fasciola gigantica. In the present study, the IIS pathway was reconstructed in F. gigantica. We defined the components involved in the IIS pathway and ...
While the AMPK signalling pathway also affects insulin action and glucose metabolism; AMPK is an energy sensor which upon activation promotes glucose transport, mitochondrial function, mTOR signalling, fatty acid oxidation and sirtuin expression, while inhibiting inflammation and JNK signalling, oxidative ...
The activation of the Akt/PKB signalling pathway in the brains of clozapine-exposed rats is linked to hyperinsulinemia and not a direct drug effect. Psychopharmacology. 2014;231:4553–60. Article CAS PubMed Google Scholar Sevak RJ, Koek W, France CP. Streptozotocin-induced diabetes differentially...
It is well studied that the PI3K/Akt/mTOR signalling pathway is a master growth regulator that promotes protein synthesis [31], so we presumed that the PI3K/Akt/mTOR pathway governs the expression of RBM20 and thus altered RBM20 expression level regulates titin splicing. We next tested the ...
insulin signalling pathway (Supplementary Fig.4). There are 33 genes exhibiting significant differences in the primary kings, primary queens, and female and male workers of the lower subterranean termites. There are two insulin signalling pathways: the mitogen-active kinase (MAPK) pathway and the ...
Dissecting the role of the Tir:Nck and Tir:IRTKS/ IRSp53 signalling pathways in vivo. Mol Microbiol 2010; 75:308-323. 14 Youngren JF. Regulation of insulin receptor function. Cell Mol Life Sci 2007; 64:873-891. 15 Wang KS, Chen G, Shen HL, et al. Insulin receptor tyrosine kinase ...
the latter decreasing more prominently in aging and diabetic populations. Atrogi’s unique discovery of receptor signalling, which treats the root cause of the disease via an insulin independent pathway, has the potential to create unique treatment opportunities and even disrupt the...
Madhusudhan, T. et al. Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.Nat. Commun.6, 6496 (2015). CASPubMedPubMed CentralGoogle Scholar Johnson, J. A., Trasino, S. E., Ferrante, A. W. Jr & Vasselli...
However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) promotes hepatic DNL during IR. ...