The gut microbiome increasingly is recognized for its role in human health and disease. Initial evidence has indicated that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate ...
The gut microbiome, i.e., the community of bacteria and other microorganisms living in the human gut, has been implicated both directly and indirectly (mediating the effects of diet) on human health [1,2]. The associations between gut microbiome composition and disease status have been widely ...
1. The human gut microbiome interaction with the immune system in age and disease 2. The gut microbiome and age-related macular degeneration 3. The gut microbiome and retinal artery occlusion 4. The gut microbiome and central serous chorioretinopathy 5. The gut microbiome and inflammatory eye ...
type 1 diabetes mellitus and pancreatic ductal adenocarcinoma. We also discuss evidence of an inherent pancreatic microbiota and the influence of the intestinal microbiota as it relates to disease association and development. In doing so, we address pitfalls in the current literature and areas of inve...
The gut microbiota has emerged as an environmental risk factor that affects thrombotic phenotypes in several cardiovascular diseases. Evidence includes the identification of marker species by sequencing studies of the gut microbiomes of patients with thrombotic disease, the influence of antithrombotic therapi...
Other types of microbes such as fungal have also been found in the TME. For example,Malasseziaspecies has been discovered in pancreatic ductal adenocarcinoma, and the glycans on its cell wall can bind to mannose-binding lectins to activate the complement cascade, which promotes tumor progression.41...
“omics” datasets become available, functional variation in the gut microbiota in response to disease, diet, or other factors may be discovered [14]. For studies focusing on the diversity of the gut microbiota, a key challenge is understanding functional redundancy (i.e., which community ...
With the prevalence of cardio-metabolic disorders reaching pandemic proportions, the search for modifiable causative factors has intensified. One such potential factor is the vast microbial community inhabiting the human gastrointestinal tract, the gut m
thedevelopmentofdisease.Basedonevidencetodate,wecanassessthe potential to positively modulate the composition of the colonic microbiota and ameliorate disease activity through bacterial intervention. Keywords: Microbiome; short-chain fatty acids; gut health; colonic metabolome; gutÁbrainÁaxis; inflammat...
The role of the microbiome in human health and disease: an introduction for clinicians. Br. Med. J. 356, j831 (2017). Article Google Scholar Barrett, K. E. & Wu, G. D. Influence of the microbiota on host physiology—moving beyond the gut. J. Physiol. 595, 433–435 (2017). ...