The gut microbiota is a complex and plastic consortium of microorganisms that are intricately connected with human physiology. The liver is a central immunological organ that is particularly enriched in innate immune cells and constantly exposed to circulating nutrients and endotoxins derived from the gut...
A challenge in characterizing associations between microbiome and alloHSCT outcomes consists in the highly dynamic nature of the gut microbiome over the course of alloHSCT31. The gut microbiome undergoes substantial temporal variation even in healthy control individuals32; In the context of alloHSCT, p...
Almost half the cells and 1% of the unique genes found in our bodies are human, the rest are from microbes, predominantly bacteria, archaea, fungi, and viruses. These microorganisms collectively form the human microbiota, with most colonizing the gut. Recent technological advances, open access dat...
Most research on the gut microbiome in colon cancer focuses on taxonomic changes at the genus level using 16S rRNA gene sequencing. Here, we develop a new methodology to integrate DNA and RNA data sets to examine functional shifts at the species level that are important to tumor development. ...
2022年3月,刘克玄教授团队在Frontiers in Cellular and Infection Microbiology期刊(中科院SCI分区小类微生物学2区,IF:5.293)上在线发表题为“Association Between Gut Dysbiosis and Sepsis-Induced Myocardial Dysfunction in Patients With Sepsis or Septic Shock”的研究论文。麻醉学2019级博士研究生陈宇和2015级八年制...
The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with athe...
Inhibitory effects of gut beneficial bacteria on 5 common pathogenic bacteria were also tested using the Oxford cup method. Results According to the results of the culture-independent method, a high abundance of four major phyla in Himalayan Griffons were identified, including Fusobacteria, ...
A new study finds that populations of bacteria in the gut are highly sensitive to the food we digest
An ever-growing body of evidence has linked the gut microbiome with both the effectiveness and the toxicity of cancer therapies. Radiotherapy is an effective way to treat tumors, although large variations exist among patients in tumor radio-responsivenes
B)Dominant microbes model: An alternative hypothesis would be that given the dominance of a small number of microbe species composing the vast majority of microbes in the gut, the concentration of each metabolite is determined by the most frequent microbe. This conceptualization translates into models...