The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tu
Recent works have also identified several other critical functions of the cGAS–STING pathway, which may also be involved in antiviral mechanisms and other chronic disease responses. For example, the cGAS–STING pathway was demonstrated to have a role in cancer and lipid metabolism as well as in ...
The cGAS-STING pathway and cancer. Nat Cancer. 2022;3:1452–63. Article CAS PubMed Google Scholar Miao L, Qi J, Zhao Q, Wu QN, Wei DL, Wei XL, Liu J, Chen J, Zeng ZL, Ju HQ, et al. Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of...
The cGAS-STING pathway: a therapeutic target in chromosomally unstable cancersdoi:10.1038/s41392-023-01328-4Haiyan YanKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of MedicineHangzhou City University 310015 Hangzhou ChinaWeiguo Lu...
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the cellu
crucial cytosolic PRR system.Altered cGAS/STING signaling supports a precancerous environment and metastasis.The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers.Current cancer therapies indirectly affect cGAS/STING signaling in tumor cells for their anticancer ...
We therefore assessed an immune based DNA Damage Repair Deficiency (DDRD) assay, that we have previously reported represents activation of the cGAS STING pathway, in the TCGA prostate cancer dataset to investigate the presence of targetable immune biology in prostate cancer. In addition we applied ...
The cGAS/STING signaling pathway comprises a crucial cytosolic PRR system. • Altered cGAS/STING signaling supports a precancerous environment and metastasis. • The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers. • Current cancer therapies indirectly affect...
During tumor progression, a subset of cancer cells escape from immune surveillance and eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor cells by enhancing multiple steps in cancer-immunity cycle including antigen prese
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015;11:1018–30. CAS PubMed PubMed Central Google Scholar Li T, Chen ZJ. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. ...