乙酰化抑制 cGAS 激活。 The cGAS‐STING pathway is highly conserved throughout biological evolution. The cGAS‐STING pathway plays a defensive role against phages in prokaryotes.This pathway is also found in the invertebrate Nematostella vectensisc,but in sea anemones, the cGAS‐STING pathway induces...
北京大学的蒋争凡团队2009年在PNAS发表ERIS, an endoplasmic reticulum IFN stimulator,activates innate immune signalingthrough dimerization文章,核心是发现STING必须二聚化后发挥功能。 图示10:STING 蛋白在TBK1-IRF3-干扰素信号通路上的重要作用 图片Ref: Aduro – STING Pathway in Cancer Immunology | Cancer Biology ...
[2] Wan D, Jiang W, Hao J. Research advances in how the cGAS-STING pathway controls the cellular inflammatory response [J/OL]. Front Immunol, 2020, 11 [2021-08-30]. https://pubmed.ncbi.nlm.nih. gov/32411126/....
关键词 : 非洲猪瘟病毒 ;天然免疫 ;cGAS‑STING 信号通路 ;免疫逃逸 DOI:10.13560/j.cnki.biotech.bull.1985.2023‑0681 Research Progress in cGAS-STING Signaling Pathway in ASFV Antagonizing Host ZHAO Hong‑yuan1 LIU Qiang2 CHENG Wen‑yu1 (1. School of Modern Agriculture and Biotechnology, ...
近日郑春福教授在Journalof Medical Virology发表研究论文“NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1” (NLRC4 通过促进 CBL 介导的 K63 连接的 TBK1 多聚...
近日,遵义医科大学药学院熊永爱博士应邀在Journal of Molecular Cell Biology(JMCB) 发表综述:The crosstalk between the caspases familyand the cGAS-STING signaling pathway,系统综述了相关领域的最新研究进展,总结了Caspases与cGAS-STING相互作用在病毒感染、癌症、炎症和自身免疫性疾病等发生发展过程中的作用及其分子机...
近期,MCE 客户澳大利亚墨尔本大学 Seth L. Masters 教授团队在 Cell 上发表了题为 TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS 的研究成果,发现在肌萎缩性侧索硬化症 (ALS,俗称渐冻症) 中,核 DNA/RNA 结合蛋白 TDP-43 通过 mPTP (线粒体通透性转换孔) 触发线粒体 ...
关键词:cGAS-STING信号通路;细胞功能;cGAS-STINGSignalingPathway; CellularFunction 1.引言 细胞固有的免疫识别机制是病原体感染和内源性DNA损伤的关键防线。在这 一机制中,cGAS(环状GMP-AMP合成酶)-STING(干扰素基因刺激物)信号通路扮 演着重要角色,其可以识别细胞内异常的DNA并激活一系列的防御响应。随着这 ...
Finally, our findings demonstrate that NLRX1 may be an additional regulator that functions upstream to regulate cGASSTING pathway. Conclusions These findings suggest that the canonical cGAS-STING-mediated Type I interferon signaling axis is a critical component of neural tissue damage following TBI and...
(11): 657-674. 3. Chien-Hsiung Yu, et al. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Cell. 2020 Oct 3; S0092-8674(20)31161-2. 4. Wang, R., et al. Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse ...