25(12), 3405–3421.e7. https://doi.org/10.1016/j.celrep.2018.11.097[15] Berger, G., & Lawler, S. E. (2018). Novel non-nucleotidic STING agonists for cancer immunotherapy. Future medicinal chemistry, 10(24), 2767–2769. https://doi.org/10.4155/fmc...
Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages 衰老的癌症细胞经常逃避免疫清除,对癌症进展和治疗耐药性产生深远影响。改善免疫监测以消除衰老的癌症细胞是加强抗癌治疗的关键措施。八子补肾是一种具有缓解疲劳和延缓衰老作...
因此,STING 作为免疫疗法靶点前景广阔,在治疗恶性肿瘤方面大有可为。 四川大学生物治疗国家重点实验室张敦房课题组和日本千叶大学Hiroko Nakatsukasa在MedComm-Oncology发表了题为“cGAS-STING Signaling in Cancer: Regulation and Therapeutic Ta...
2020年1月,来自美国纪念斯隆-凯特琳癌症中心的Samuel F. Bakhoum教授团队在Cancer Discov.上发表题为'The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer'的综述性论文。该文章总结提出:根据具体情况,cGAS-STING信号传导也可以有促进肿瘤...
这些挑战和未知将有助于推动对这一途径的持续研究,这一领域新的发现将使STING激动剂在癌症免疫治疗中发挥更大的作用。 参考文献: 1. Targeting STING for cancer immunotherapy: From mechanisms to translation. Int Immunopharmacol.2022 Dec;113(Pt A):109304...
Tumor Suppressive Roles of cGAS-STING. Kwon J, et al. The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer. Cancer Discov. 2020. cGAS-STING通路在免疫学、肿瘤学和感染疾病等多个领域具有重要的应用潜力。 癌症免疫疗法 增强免疫应答:cGAS-STING通路通过识别肿瘤细胞内的DNA(如突变DNA或病毒相关DNA),可...
cGAS- STING and cancer: dichotomous roles in tumor immunity and development. Trends Immunol 2018; 39: 44-54.Ng KW, Marshall EA, Bell JC, Lam WL. cGAS-STING and cancer: dichotomous roles in tumor immunity and de- velopment. Trends Immunol. 2018;39(1):44-54....
Woo SR et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014 Nov 20;41(5):830-42. Li S et al. STING-induced regulatory B cells compromise NK function in cancer immunity. Nature. 2022 Oct 5....
近日,来自海南医科大学第一临床学院的研究者们在J Nanobiotechnology杂志上发表了题为“A metal-organic nanoframework for efficient colorectal cancer immunotherapy by the cGAS-STING pathway activation and immune checkpoint blockade”的文章,该研究揭示了金属-有机纳米框架通过cGAS-STING通路激活和免疫检查点阻断可治疗...
2024年9月,《J Immunother Cancer》杂志上发表了题为“Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway”的研究论文,该研究通过免疫组织化学和免疫荧光方法检测151例癌症胰腺癌组织中ANXA1和c-Casp3的表达及肿...