2024年9月,《J Immunother Cancer》杂志上发表了题为“Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune microenvironment in pancreatic cancer by activating the cGAS/STING pathway”的研究论文,该研究通过免疫组织化学和免疫荧光方法检测151例癌症胰腺癌组织中ANXA1和c-Casp3的表达及肿...
STING agonists co-administrated with other cancer immunotherapies, including cancer vaccines, immune checkpoint inhibitors such as anti-programmed death 1 and cytotoxic T lymphocyte-associated antigen 4 antibodies, and adoptive T cell transfer therapies, would hold a promise of treating medium and ...
Recent works have also identified several other critical functions of the cGAS–STING pathway, which may also be involved in antiviral mechanisms and other chronic disease responses. For example, the cGAS–STING pathway was demonstrated to have a role in cancer and lipid metabolism as well as in ...
2020年1月,来自美国纪念斯隆-凯特琳癌症中心的Samuel F. Bakhoum教授团队在Cancer Discov.上发表题为'The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer'的综述性论文。该文章总结提出:根据具体情况,cGAS-STING信号传导也可以有促进肿瘤...
Tumor Suppressive Roles of cGAS-STING. Kwon J, et al. The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer. Cancer Discov. 2020. cGAS-STING通路在免疫学、肿瘤学和感染疾病等多个领域具有重要的应用潜力。 癌症免疫疗法 增强免疫应答:cGAS-STING通路通过识别肿瘤细胞内的DNA(如突变DNA或病毒相关DNA),可...
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tu
近日,来自郑州大学第一附属医院医学研究中心的研究者们在J Control Release.杂志上发表了题为“A polymeric nanoplatform enhances the cGAS-STING pathway in macrophages to potentiate phagocytosis for cancer immunotherapy”的文章,该研究不仅建立了STING通路与细胞代谢之间的重要联系,而且为癌症治疗提供了潜在的组合策略...
10. YANG C, LIANG Y, LIU N, et al. Role of the cGAS-STING pathway in radiotherapy for non-small cell lung cancer[J]. Radiat Oncol, 2023,18(1):145. 编辑| 宁然 排版| 张志远 审核| 王汝斌 联系电话 | 0531-88953343
Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanica...
近日,来自海南医科大学第一临床学院的研究者们在J Nanobiotechnology杂志上发表了题为“A metal-organic nanoframework for efficient colorectal cancer immunotherapy by the cGAS-STING pathway activation and immune checkpoint blockade”的文章,该研究揭示了金属-有机纳米框架通过cGAS-STING通路激活和免疫检查点阻断可治疗...