The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tu
Recent works have also identified several other critical functions of the cGAS–STING pathway, which may also be involved in antiviral mechanisms and other chronic disease responses. For example, the cGAS–STING pathway was demonstrated to have a role in cancer and lipid metabolism as well as in ...
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. Howe
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the cellu
The cGAS/STING signaling pathway comprises a crucial cytosolic PRR system. • Altered cGAS/STING signaling supports a precancerous environment and metastasis. • The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers. • Current cancer therapies indirectly affect...
crucial cytosolic PRR system.Altered cGAS/STING signaling supports a precancerous environment and metastasis.The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers.Current cancer therapies indirectly affect cGAS/STING signaling in tumor cells for their anticancer ...
103 Background: Recent studies have demonstrated limited success of immune checkpoint therapies in unselected prostate cancer. We therefore assessed an immune based DNA Damage Repair Deficiency (DDRD) assay, that we have previously reported represents activation of the cGAS STING pathway, in the TCGA ...
Recently, a series of studies demonstrated that the vital component of host innate immunity — cGAS-STING pathway might play an important role in anti-cancer immunity. It is generally acknowledged that the downstream signals of cGAS-STING especially type I interferon (IFN) bridge innate immunity ...
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015;11:1018–30. CAS PubMed PubMed Central Google Scholar Li T, Chen ZJ. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. ...
Recently, cancer immunotherapy has emerged as an efficient treatment against some cancers. Here we have used a mouse model of mutagen-induced HCC to explore the therapeutic usefulness of targeting the DNA-activated STING pathway in HCC. STING-deficient mice exhibited unaltered initial development of ...