cGAS-STING pathwayCancer biotherapyInterferonCyclic dinucleotideAgonistDelivery systemClinical trialsThe activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have witnessed that producing dsDNA upon various stimuli...
cGAS-STING pathway in cancer biotherapy 来自 Semantic Scholar 喜欢 0 阅读量: 168 作者:Y Wang,J Luo,A Alu,X Han,X Wei 摘要: The activation of the cGAS-STING pathway has tremendous potential to improve anti-tumor immunity by generating type I interferons. In recent decades, we have ...
cGAS-STING pathway in cancer biotherapy. Mol. Cancer 19, 136 (2020). Article CAS PubMed PubMed Central Google Scholar Bakhoum, S. F. et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553, 467–472 (2018). Article ADS CAS PubMed PubMed Central ...
cGAS-STING pathway in cancer biotherapy. Mol. Cancer 19, 136 (2020). Article CAS PubMed PubMed Central Google Scholar Bakhoum, S. F. et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553, 467–472 (2018). Article ADS CAS PubMed PubMed Central ...
Du, H. S.; Xu, T. M.; Cui, M. H. cGAS-STING signaling in cancer immunity and immunotherapy.Biomed. Pharmacother.2021,133, 110972 CASPubMedGoogle Scholar Samson, N.; Ablasser, A. The cGAS-STING pathway and cancer.Nat. Cancer2022,3, 1452–1463. ...
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING sig
Immunotherapy has shown marked progress in promoting systemic anti-colorectal cancer (CRC) clinical effects. For further effectively sensitizing CRC to immunotherapy, we have engineered a pH-sensitive zeolitic imidazolate framework-8 (CS/NPs), capable of efficient cGAS-STING pathway activation and immune...
The impacts of anlotinib on radiation and tumor immune microenvironment (TIME) in NSCLC remain to be resolved. Here, we find anlotinib enhances radiosensitivity, and further increases radiotherapy-stimulated CD8T cell infiltration and activation via triggering cGAS/STING pathway. Moreover, anlotinib ...