The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tu
Recent works have also identified several other critical functions of the cGAS–STING pathway, which may also be involved in antiviral mechanisms and other chronic disease responses. For example, the cGAS–STING pathway was demonstrated to have a role in cancer and lipid metabolism as well as in ...
crucial cytosolic PRR system.Altered cGAS/STING signaling supports a precancerous environment and metastasis.The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers.Current cancer therapies indirectly affect cGAS/STING signaling in tumor cells for their anticancer ...
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage. Underlying this broad involvement of the cGAS–STING pathway is its capacity to sense and regulate the cellu
The cGAS/STING signaling pathway comprises a crucial cytosolic PRR system. • Altered cGAS/STING signaling supports a precancerous environment and metastasis. • The cGAS/STING pathway also serves as a potential prognostic biomarker in different cancers. • Current cancer therapies indirectly affect...
103 Background: Recent studies have demonstrated limited success of immune checkpoint therapies in unselected prostate cancer. We therefore assessed an immune based DNA Damage Repair Deficiency (DDRD) assay, that we have previously reported represents activation of the cGAS STING pathway, in the TCGA ...
During tumor progression, a subset of cancer cells escape from immune surveillance and eventually develop into measurable tumor mass. Cancer immunotherapy eradicates tumor cells by enhancing multiple steps in cancer-immunity cycle including antigen prese
Consequently, there has been a surge in research investigating medical agents or mediators targeting cGAS-STING signaling. Interestingly, therapeutic manipulation of the cGAS-STING pathway has yielded inconsistent and even contradictory effects on different liver diseases due to the distinct physiological ...
Chromosomal instability (CIN) in cancer cells has been reported to activate the cGAS–STING innate immunity pathway via micronuclei formation, thus affecting tumor immunity and tumor progression. However, adverse effects of the cGAS/STING pathway as they relate to CIN have not yet been investigated....
Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 2015;11:1018–30. CAS PubMed PubMed Central Google Scholar Li T, Chen ZJ. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. ...