此外,cGAS-STING 通路的激活还与肿瘤消退、延长癌症患者生存期和增强免疫疗法有关。因此,STING 作为免疫疗法靶点前景广阔,在治疗恶性肿瘤方面大有可为。 四川大学生物治疗国家重点实验室张敦房课题组和日本千叶大学Hiroko Nakatsukasa在MedComm-...
9. Du M, Chen ZJ. DNA-induced liquid phase condensation of cGAS activates innate immune signaling. Science. 2018; 361: 704–709. doi: 10.1126/science.aat1022. 10. Zheng J, et al. Comprehensive elaboration of the cGAS...
Additionally, the cGAS-STING pathway promotes the senescence of cancer cells, induces apoptosis of cancer cells, and increases the protective effect of cytotoxic T cells and natural killer cell-mediated cytotoxicity. We believe that the combination of the cGAS-STING signaling pathway with other ...
CANCERCellular communication is necessary for organizing multicellular organisms,and is critical in tumorigenesis and progression.Immune and tumor cells use the cGAS-STING mechanism to sense and respond to genomic instability,DNA damage,and mitochondrial dysfunction induced by extra-and intracellular stresses...
2. cGAS/STING signaling pathway is crucial in maintaining cellular homeostasis 3. cGAS/STING signaling in cancer cells 4. Current cancer therapies indirectly affect cGAS/STING in cancer cells 5. Future perspective and conclusion Informed Consent Statement Funding CRediT authorship contribution statement De...
Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages 衰老的癌症细胞经常逃避免疫清除,对癌症进展和治疗耐药性产生深远影响。改善免疫监测以消除衰老的癌症细胞是加强抗癌治疗的关键措施。八子补肾是一种具有缓解疲劳和延缓衰老作...
Geneviève,Pépin,Michael,... - 《Regulation of Inflammatory Signaling in Health & Disease》 被引量: 9发表: 2017年 STING-mediated DNA sensing in cancer immunotherapy While STING (STimulator of INterferon Genes) has been shown to be essential for cytosolic DNA-triggered innate immune activation, ac...
Basis of STING signaling pathway cGAS-STING pathway The cGAS-STING pathway is the central cellular cytosolic double-stranded DNA (dsDNA) sensor, allowing innate immune to respond to infections, inflammation, and cancer [8, 9]. Both intrinsic and extrinsic self-DNA sensing can contribute to its ...
cGAS-STING, an important pathway in cancer immunotherapy Article Open access 22 June 2020 STING pathway as a cancer immunotherapy: Progress and challenges in activating anti-tumor immunity Article 05 April 2024 Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and ...
鸦胆子苦醇通过激活 cGAS-STING 信号通路 抑制肝癌 H22 荷瘤小鼠肿瘤生长 ,增强其免疫功 能 ,但由于机制复杂 ,仍需继续探索. 利益冲突 所有作者均声明不存在利益冲突 参考文献 [1] Anwanwan D, Singh S K, Singh S, et al. Challenges in liver cancer and possible treatment approaches [J]. Biochim ...