2021年1月8日, 美国北卡罗来纳大学教堂山分校微生物与免疫系万谊松教授团队(伍兵博士为第一作者)在Immunity上发表了文章The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation,揭示了自身免疫疾病中T细胞内源性的Activin-A信号而不是...
近日,布莱根妇女医院、哈佛医学院的Richard S. Blumberg研究组(第一作者段金志博士,共同第一作者是Juan D. Matute)对上述问题进行了探索,在Immunity发表了最新研究论文,题为:Endoplasmic reticulum stress in intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut,...
2021年1月8日, 美国北卡罗来纳大学教堂山分校微生物与免疫系万谊松教授团队(伍兵博士为第一作者)在Immunity上发表了文章The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differen...
Li P, Guo Z, Wan YY. SKI Expression Suppresses Pathogenic Th17 Cell Response and Mitigates Experimental Autoimmune Encephalomyelitis. Front Immunol. 2021 Jul 15;12:707899. doi: 10.3389/fimmu.2021.707899. PMID: 34335622; PMCID: PMC8321777. Chong WP, Mattapallil MJ...
Figure 1. Th17 Cell Differentiation in Mouse and Man (A) In mouse, naive T cells activated in the presence of TGF-β (possibly provided by Treg cells) and IL-6 begin differentiation toward the Th17 cell subset; IL-6 upregulates IL-21 and IL-23R to further their Th17 development. In ...
Moreover, TNFα promoted Th17 cell differentiation through IL-6 and IL-1β produced by monocytes in active RA patients. Patients with active RA that response to anti-TNFα therapy produced less Th17 cells than the pretreatment. These data suggest that TNFα promotes Th17 cell differentiation ...
However, the role of IRF8 in CD4(+) T-cell development is less well defined, with a recent study implicating IRF8 as an intrinsic repressor of interleukin-17 (IL-17) expressing T helper type 17 (Th17) cell differentiation. Using an IRF8-EGFP reporter strain we have confirmed that IRF8...
除此之外,IL-38也被证实可以下调IL-17信号通路,降低Th17细胞致病性相关基因Csf2和Il23r的表达。体外模型中显示,IL-38降低GM-CSF的刺激功能,抑制IL-23R表达。IL-27信号上调则可以抑制Th17细胞产生GM-CSF。 衰老带来的免疫系统变化也体现在致病性Th17细胞中。小鼠模型显示: 当面临自身免疫挑战时, 与年轻小鼠相比,老年...
TNF α Promotes Th17 Cell Differentiation through IL-6 and IL-1 β Produced by Monocytes in Rheumatoid Arthritis[J] . Yingxia Zheng,Lei Sun,Ting Jiang... Sujata,Sarkar,and,... - 《Rheumatic Disease Clinics of North America》 被引量: 119发表: 2010年 Upregulated KAT7 in synovial fibroblasts...
Family members of peroxisome proliferator-activated receptors (PPARs), such as PPARγ, have been shown to be effective in regulating T helper 17 (Th17) cell differentiation. However, whether PPARα, another important family member of PPARs, contributes to Th17 cell differentiation remains controversi...