Chapter 2Th1/Th2 Cell Differentiationand Molecular SignalsYuan Zhang, Yaguang Zhang, Wangpeng Gu and Bing SunAbstract The distinctive differentiated states of the CD4+ T helper cells are deter-minedbythesetoftranscriptionfactorsandthegenestranscribedbythetranscriptionfactors. In vitro induction models, ...
Helper T cells are found in two distinct cell types, Th1 and Th2, distinguished by the cytokines they produce and respond to and the immune responses they are involved in. Th1 cells produce pro-inflammatory cytokines like IFN-g, TNF-b and IL-2, while Th2 cells produce the cytokines IL-...
differentiationImmune effector cell多发性硬化Most of immunopathological knowledge on multiple sclerosis(MS) is from studies based on the hypothesis that MS is a Th1 disease. Understanding differentiation and crossregulation of Th1 and Th2 cells is pivotal to grasp the immunological theories of MS. ...
此外,WPH干预后,Th1/Th2平衡恢复、IgA分泌增加,肠道有益菌数量增加、产生有益SCFAs、促进肠道免疫耐受,最终食物过敏症状得到缓解。该研究结果可能为缓解乳清蛋白食物过敏提供潜在的预防策略。 Abstract Whey protein, a by-product of cheese processing, is ubiquitously applied in infant formula. Nevertheless, it cont...
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乳清蛋白引起的食物过敏症状通过WPH的早期干预得到缓解,表现为过敏症状的减轻和I型超敏反应标志性指标IgE水平的降低。此外,WPH干预后,Th1/Th2平衡恢复、IgA分泌增加,肠道有益菌数量增加、产生有益SCFAs、促进肠道免疫耐受,最终食物过敏症状...
IL-5 stimulates eosinophil responses, also part of the immune response toward large extracellular parasites (see “IL-5 Signaling Pathway”) Th1 and Th2 are produced by differentiation from a non-antigen exposed precursor cell type, Thp. Exposure of Thp cells to antigen by antigen-presenting ...
一氧化氮——NF—κB信号通路在人初始T细胞向Th1/Th2分化中的作用ISSN1007—8738细胞与分子免疫学杂志(ChinJCellMolhnmuno1)2004,20(2?论着?一氧化氨215文章编号:1007—8738(2004)02—0215—03NF?KB信号通路在人初始T细胞向Thl/Th2分化中的作用张宁,徐永健,张珍祥,邓群益,熊维宁,刘先胜(华中科技大学同济医学院...
目的:探讨子宫内膜异位症(EMT)患者外周血T辅助淋巴细胞(Th细胞)分泌干扰素(IFN-γ),白细胞介素(IL-2,4,10)水平异常的意义.方法:选取EMT确诊病例40例作为EMT组,正常女性为对照组.分别分离出两组外周血清中的Th细胞,采用双抗夹心Elisa法检测其IFN-γ以及IL-2,4,10的水平,并计算IFN-γ/IL-4,IL-2/IL-10的...
复旦大学 博士学位论文 细胞信号转导介导日本血吸虫特异性Th1/Th2免疫偏移及其意义 姓名:*** 申请学位级别:博士 专业:生化与分子生物学 指导教师:**良 2001.5.1 细胞信号转导介导日本血吸虫特异性Thl/Th2免疫偏及其意义 摘要 血吸虫病的主要危害是虫卵肉芽肿病变并导致肝纤维化,目前尚无 有效控制方法。近年来研究...