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Helper T cells are found in two distinct cell types, Th1 and Th2, distinguished by the cytokines they produce and respond to and the immune responses they are involved in. Th1 cells produce pro-inflammatory cytokines like IFN-g, TNF-b and IL-2, while Th2 cells produce the cytokines IL-...
IL-5 stimulates eosinophil responses, also part of the immune response toward large extracellular parasites (see “IL-5 Signaling Pathway”) Th1 and Th2 are produced by differentiation from a non-antigen exposed precursor cell type, Thp. Exposure of Thp cells to antigen by antigen-presenting ...
Chapter 2Th1/Th2 Cell Differentiationand Molecular SignalsYuan Zhang, Yaguang Zhang, Wangpeng Gu and Bing SunAbstract The distinctive differentiated states of the CD4+ T helper cells are deter-minedbythesetoftranscriptionfactorsandthegenestranscribedbythetranscriptionfactors. In vitro induction models, ...
TH1/TH2 cell differentiation and molecular signals. Adv Exp Med Biol. 2014; 841: 15-44.Zhang Y, Zhang Y, Gu W, Sun B. TH1/TH2 cell differentiation and molecular signals. Adv Exp Med Biol. 2014;841:15-44.Zhang Y, Zhang Y, Gu W, Sun B. TH1/TH2 cell differentiation and ...
中南大学硕士学位论文Th1/Th2型细胞因子失衡与自身免疫性甲状腺疾病的关系研究姓名:***请学位级别:硕士专业:免疫学指导教师:**国20050528颧士学位论文中文擒要摘要目的:分析自身免疫性甲状腺疾病(AITD)患者血清Thl/Th2型细胞因子含量与抗甲状腺自身抗体水平的相关性,探讨甲状腺Thl/Th2细胞免疫失衡与AITD发病的关系。方法...
The function role of GATA-3 in Th1 and Th2 differentiation GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the ... Meixia,ZhouWenjun,Ouyang - 《Immunologic Research》 被引量: 305发表:...
摘要: PROBLEM TO BE SOLVED: To provide a new screening system retrieving compounds associated to Ras/MAPK passage or Ca/CN passage, or compounds modifying human Th1/Th2 differentiation induction under the condition in which the prescribed passages are acting....
These findings elucidate a novel mechanism of action of CC-4047 on T cell differentiation, suggesting that certain IMiDs immunomodulatory drugs may have expanded clinical application in treating both allergic diseases and certain T cell lymphomas where a predominant Th2 phenotype is displayed. 展开 ...
机体清除病原体需要辅助性T细胞的参与,根据其产生细胞因子的不同可将辅助性T细胞分为两类:Th1细胞和Th2细胞.GATA3在调节Th1和Th2细胞分化中起重要作用.转录因子GATA家族(GATA-3)不仅在转录水平上调节Th2类细胞因子的表达,而且在染色体结构的重组和IL-4位点的开放方面都起着重要的作用.作为一个重要的调控,GATA3通...