RATIONALE: Murine IL-27 is a potent suppressor of Th2 cell differentiation. However, it is unknown whether murine IL-27 suppresses Th2 cytokine production by differentiated Th2 cells and if so which signaling pathway murine IL-27 uses. Moreover, it is unclear if human IL-27 suppresses Th2...
2 T-helper 2 cellsT-helper (Th) 2 cells, which produce interleukin (IL)-4, IL-5, IL-10 and IL-13 upon stimulation of their T cell receptors, play an important role in the develop- ment of human allergic diseases. However, the precise mechanism involved in the differentiation of Th2...
DIFFERENTIATION GENE REGULATION IN IMMUNE CELLS SYSTEMS BIOLOGY CELL SIGNALLING Received 27 April 2012 Accepted 1 June 2012 Published 18 June 2012 Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation Ubaid Ullah1, Parul Tripathi1, Riitta Lahesmaa2 & ...
英文别名: CellXVivo Human Th2 Cell Differentiation Kit (1 KT)中文名: 中文别名: CBNumber: CB35616762 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 6 CellXVivo Human Th2 Cell Differentiation Kit (1 KT)化学性质 ...
Th2 differentiation of converted FOXP3(-) ex-Treg occurred even under nonpolarizing conditions and could not be prevented by IL-4 signaling blockade. Thus, our studies identify Th2 differentiation as the default developmental program of human Treg after downregulation of FOXP3. 展开 ...
Moreover, GATA-3 mRNA levels increased under Th2-inducing conditions and decreased under Th1-inducing conditions. Taken together, the data strongly suggest that GATA-3 is an important transcription factor in regulating human Th2 cell differentiation in vivo. 展开 关键词: Th1/Th2 cells cellular ...
1␣,25(OH)2D3 Inhibits Not Only Th1 But Also Th2 Differentiation in Human Cord Blood T Cells JOSEFA PICHLER, MARIANNE GERSTMAYR, ZSOLT SZÉPFALUSI, RADVAN URBANEK, MEINRAD PETERLIK, AND MARTIN WILLHEIM Department of Pediatrics, University of Vienna, A-1090 Vienna, Austria (J.P., M...
CD81, a cell-surface protein of the tetraspanin superfamily, has been shown to costimulate T cell activation in murine T cells, and is involved in development of Th2 immune responses in mice. Results Here it is shown that stimulation of CD81 on human T cells can enhance T cell activation...
Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in ... The effect of progesterone (P) on the cytokine production profile of Ag-specific human CD4+ T cell lines and clones was investigated. ...
Human Th2 gene locusThe differentiation of mouse nave CD4 T cells into type 2 helper (Th2) cells is accompanied by chromatin remodeling at the nucleosomes associated with the IL-4, IL-13 and IL-5 genes. However, little is known about how chromatin remodeling of these Th2 cytokine gene ...