针对这一科学问题,近期中山大学施松涛教授等研究者在Cell Metabolism杂志上发表的一篇题为“Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation”的文章,该研究提出细胞凋亡是机体硫化氢稳态的重要来源,同时提出干细胞外囊泡...
3. To further identify their roles, the differentiation and regulation of Th17 cells has been widely explored recently. Th17细胞作为一个不同于Th1、Th2的细胞亚群,已经被证实在自身免疫病、感染等疾病中发挥重要的作用。更多例句>> 2) Th17 cell Th17细胞 1. Research progress on Th17 cells; Th17...
Figure 1. Th17 Cell Differentiation in Mouse and Man (A) In mouse, naive T cells activated in the presence of TGF-β (possibly provided by Treg cells) and IL-6 begin differentiation toward the Th17 cell subset; IL-6 upregulates IL-21 and IL-23R to further their Th17 development. In ...
CD4+辅助性T淋巴细胞是细胞免疫的介质,在活化其他免疫细胞(如B细胞和细胞毒性T细胞)以及调节免疫反应中起着关键作用。CD4+辅助性T细胞进一步分化为以细胞因子分泌和效应功能为特征的亚群,这些亚群在外周由固有免疫细胞的诱导而实现分化[1]。首先...
2023年12月18日，中山大学施松涛、中国科学院生物物理研究所陈畅等人在 Cell 子刊 Cell Metabolism 上发表了题为：Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation 的研究论文【1】。该研究揭示了细胞凋亡在维持H2S稳态中的一个之前未知的作用，发现了凋亡细胞产生的凋亡囊泡（apoV）继承了H2S...
TNFa: Promotes Thl7 Cell Differentiation through IL-6 and IL-1 beta Produced by Monocytes in Rheumatoid Arthritis TNFα promotes Th17 cell differentiation through IL-6 and IL-1β produced by monocytes in rheumatoid arthritis. J Immunol Res. 2014;2014:385352... Lei,Sun,Ting,... - 《Clinical...
Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype Mesenchymal stem cells (MSCs) exert immunomodulatory properties via the inhibition of T cell activation and proliferation. Because of the deleterious role ... S Ghannam,J Pène,G Torcy...
(Il17ra KO) conferred protection to smoking-induced arthritis aggravation. Moreover, in vitro experiments showed that cigarette smoke can directly increase Th17 differentiation of T cells by inducing AHR activation. Indeed, Ahr KO mice were protected from cigarette smoke-induced arthritis aggravation and...
Despite their importance, the molecular circuits that control the differentiation of naive T cells remain largely unknown. Recent studies that reconstructed regulatory networks in mammalian cells have focused on short-term responses and relied on perturb
cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell ...