In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. In embryonic stem cells, telomerase is activated and ...
Telomeres and telomerase in cancer stem cells端粒和端粒酶与肿瘤干细胞的研究现状 摘要 端粒通过动力学的改变能抑制和促进恶性转化来调控基因组稳定性和细胞寿命。由端粒功能障碍引发调控机制在抑制癌症生成中发挥了重要作用,而端粒粒缩短引发染色体的不稳定性是诱导肿瘤发生的原因之一。由于干细胞一直暴露在各种致癌性的...
Telomerase Activity, mTert Gene Expression and the Telomere Length in Mouse Mesenchymal Stem Cells in the Late Period after γ- and γ,n-Irradiation and in... In proliferating normal and tumor cells, the telomere length (TL) is maintained by high telomerase activity (TA). In the absence of...
Telomere and telomerase in stem cells. Br. J. Cancer 96, 1020–1024 (2007). Article CAS PubMed PubMed Central Google Scholar Armanios, M. et al. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc. Natl. Acad. Sci. ...
T cells telomerase摘要 Telomeres are specialized repeats, present at the end of chromosomes, whose loss during cell division is followed by growth arrest, a central mechanism of replicative senescence in human cells. Telomere length in stem cells is maintained by telomerase, a specialized reverse tra...
Here we review telomerase function in the biology of the hematopoietic system, in normal or differentiation and its influence on the ageing of hematopoietic stem cells. The constant cellular renewal required to maintain the hematopoietic system, provides embryonic stem cells, as well as malignant ...
In stem cells, the telomere lengths and expression of hTERT is slightly lower than that of germline cells, however, they do follow the same trend of independence relative to time and/or the number of cellular divisions. During the division of somatic cells, telomere length and hTERT expression...
Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: Clinical impacts in cancer 2018, Journal of Biomedical Science Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers 2008, Cancer Science Telomere and telomerase in stem cells 2007, British...
aAlternative CD44 splicing in intestinal stem cells and tumorigenesis 接合在小肠干细胞和tumorigenesis的选择CD44[translate] aLook at this Earth 100, and parched. 看这地球100和烘。[translate] aTRAPping telomerase within the intestinal stem cell niche 诱捕telomerase在小肠干细胞适当位置之内[translate]...
L. The role of telomeres in stem cells and cancer. Cell 152, 390–393 (2013). PubMed Google Scholar Aubert, G. Telomere dynamics and aging. Prog. Mol. Biol. Transl Sci. 125, 89–111 (2014). CAS PubMed Google Scholar Amit, M. et al. Clonally derived human embryonic stem cell ...