Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere...
Telomeres and telomerase in cancer stem cells端粒和端粒酶与肿瘤干细胞的研究现状 摘要 端粒通过动力学的改变能抑制和促进恶性转化来调控基因组稳定性和细胞寿命。由端粒功能障碍引发调控机制在抑制癌症生成中发挥了重要作用,而端粒粒缩短引发染色体的不稳定性是诱导肿瘤发生的原因之一。由于干细胞一直暴露在各种致癌性的...
2014) and stem cells, telomeres, hormones and lifestyle were the highlights this year. Every year there seems to be something new to learn. Truly, there were a lot of talks about stem cell treatments, about how lifestyle changes can be healing and how telomeres are in ...
Telomere is the complex of terminal DNA repetitive sequence and specific binding protein. Telomere is at the end of the chromosome in eukaryotic cells and protects chromosomes. The changes of telomeres' length can show self-renewal and replicate ability of stem cells. Telomere length is regulated ...
Therefore the shorter telomeres of cancer cells as compared to age-adjusted controls suggest a cell of cancer origin in the post-stem cell compartments consistent with telomere length stabilization seen after crisis [14] (and likely after transformation). On the other hand, acquisition of self-...
Biochimica et Biophysica Acta Dyskeratosis congenita , stem cells and telomeres Stem cellCancer stem cellDyskeratosis congenitaAplastic anemiaIdiopathic pulmonary fibrosisTelomeres, guanine-rich tandem DNA repeats of chromosomal ends, provide ... M Kirwan,I Dokal 被引量: 178发表: 2009年 ...
they varied telomerase activity. Perhaps not surprisingly, cells with too little telomerase had very short telomeres and eventually the cells died. Conversely, cells with augmented levels of telomerase had very long telomeres. But instead of these cells thriving, their telomeres developed instabilities....
Telomeres, the short repeat sequences at the chromosome ends in eukaryotic organisms (Greider,1991; Blackburn,2001), are indispensable for the maintenance of genome stability (Londono-Vallejo,2004; Zhang et al.,2018). Telomere erosion induces cellular senescence in human cells (Proctor and Kirkwood...
In recent years, stem cell therapy has become a very promising and advanced scientific research topic. The development of treatment methods has evoked great expectations. This paper is a review focused on the discovery of different stem cells and the potential therapies based on these cells. The ...
作者: E Hiyama 摘要: SynonymsGuanine-rich tandem DNA repeats of chromosomal ends; Telomeric repeats of stem cellsDefinitionTelomeres are guanine-rich tandem DNA repeats that cap the ends of eukaryotic chromosomes. Their p DOI: 10.1007/978-3-642-27841-9_5493-2 收藏...