telomeres in fotoreticolabili acrylic grafts, their synthesis and their applications in coating of metals Telomeres are non-coding protective sequences found at the end of linear chromosomes. They are made of repeating sequences, for example TTAGGG in vertebrat... B Gerard,DW Jean,P Yves,......
telomeres in fotoreticolabili acrylic grafts, their synthesis and their applications in coating of metalsBAUDUIN GERARDDEISS WILLY JEANPIETRASANTA YVESBOUTEVIN BERNARD
(ESCs) could be used in this same manner, however ESCs would not be autologous and face political, as well as ethical challenges because cells are derived from human embryos. In addition, because of their pluripotency there is concern for teratoma formation. For iPSCs, there is the added ...
Reactivation of telomerase in cultured human cells extends their replicative life span beyond the Hayflick limit. How telomere shortening triggers cell senescence and whether it contributes to aging in vivo are under investigation. Studies in yeast have revealed another site critical to cellular aging:...
Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTA
The discovery of telomeres and telomerase have solved the linear chromosome "end-replication problem",clarified how the end of linear chromosomes can be replicated during cell division,as well as how linear chromosomes are protected against degradation.Pairs of telomere and telomerase study also deepen...
Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the mechanistic underpinnings of telomeres and telomerase and their roles in ageing and disease. Three decades ago, the classic view was that tel...
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase. Chia-Yu...
Given the different aspects of telomeres that complicate their replication, it is not surprising that multiple DNA helicases promote replication of telomeric DNA. This review focuses on one such class of DNA helicases, the Pif1 family of 5′–3′ DNA helicases. In budding and fission yeasts,...
ESCs naturally express high levels of TERRA, consistent with their long telomeres and a need to regulate telomere length. TERRA is known to be regulated in a cell-cycle-dependent manner (Porro et al., 2010), with low levels in late S phase when telomere replication and telomerase recruitment...