telomeres in fotoreticolabili acrylic grafts, their synthesis and their applications in coating of metalsBAUDUIN GERARDDEISS WILLY JEANPIETRASANTA YVESBOUTEVIN BERNARD
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend their telomeres independent of telomerase. Chia-Yu...
Cite this chapter Siomos, M.F., Riha, K. (2012). Telomeres and Their Biology. In: Wendel, J., Greilhuber, J., Dolezel, J., Leitch, I. (eds) Plant Genome Diversity Volume 1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1130-7_5...
9,10 While it is unclear whether ECTRs fulfill a perpetuating role in the ALT mechanism by providing a template for telomere synthesis, or whether they are simply generated as a by-product of the pathway, their prevalence highlights substantial inefficiencies in telomere length maintenance by ALT....
Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTA
Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which include their composition in multimers of TTA
Many recent advances have emerged in the telomere and telomerase fields. This Timeline article highlights the key advances that have expanded our views on the mechanistic underpinnings of telomeres and telomerase and their roles in ageing and disease. Three decades ago, the classic view was that tel...
Nishizaki T, DeVries S, Chew K, Goodson WH, Ljung BM, Thor A, Waldman FM: Genetic alterations in primary breast cancers and their metastases: direct comparison using modified comparative genomic hybridization. Genes Chromosomes Cancer. 1997, 19: 267-272. 10.1002/(SICI)1098-2264(199708)19:4<...
There are many theories of biological aging, such as the Cellular Aging Theory, Immunological Theory, and the Wear and Tear Theory. The Cellular Aging theory describes the process of aging in which cells slow their number of replication, thus giving each species a “biological clock that ...
Thus, telomere length and their integrity are regulated at many different levels, and we only start to understand this process under conditions of increased oxidative stress, inflammation and during diseases as well as the ageing process. This chapter aims to describe our current state of knowledge...