This loss is replenished by highly conserved telomere elongation pathways operating mainly during gametogenesis and in early stages of embryogenesis, to allow development, and tissue renewal throughout life. Herein, we discuss the structure and function of telomeres, the mechanisms of telomere capping ...
Structure and function of telomeres. The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent wo... E H,Blackburn - 《Nature》 被引量: 6110发表: 1991年 Structure and function of telomerase RNA Main...
Telomerase is a unique ribonucleoprotein reverse transcriptase that uses an integral RNA template to catalyze the addition of telomeric repeats at telomeres. This mechanism is required for the maintenance of chromosome termini, as the structure and integrity of telomeres are essential for genome stability...
内容提示: Telomere structure and function Daniela Rhodes and Rafael Giraldo Medical Research Council Laboratory of Molecular Biology, Cambridge, UK and Consejo Superior de Investigaciones Cientificas Centro de Investigaciones Biol6gicas, Madrid, Spain Telomeres, the termini of linear eukaryotic chromosomes,...
Conclusions and future prospects To better understanding of the essential biological role of telomeres is a clear need to reveal the structure and function of telomere RNA.74 RNA telomere G-quadruplexes is a valuable target for anticancer ligands.18 Human telomere DNA–RNA hybrid G-quadruplexes pro...
被引量: 1962发表: 2009年 Structure and function of telomeres. The DNA of telomeres--the terminal DNA-protein complexes of chromosomes--differs notably from other DNA sequences in both structure and function. Recent wo... E,H,Blackburn - 《Nature》 被引量: 6700发表: 1991年 加载更多来源...
reverse transcriptase and several factors that can recruit and assemble telomerase to telomeres in a cell cycle-dependent manner, we compare and discuss here recent findings in telomerase biology in cancer, aging and parasitic diseases to give a broader perspective of telomerase function in human ...
Regions of permanently densely packaged and transcriptionally silent chromatin that are found at specific, highly repetitive regions of the genome, such as telomeres and centromeres. Pre-initiation complex A large complex of proteins, including RNA polymerase II and its associated general transcription fa...
Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has ... H Blackburn 被引量: 0发表: 1990年 Blackburn EHStructure and function of telomeres. Nature 350: 569-573 The DNA of telomeres--the termin...
Telomerase is an enzyme that is employed in rapidly dividing cells such as embryonic stem cells and sperm in order to maintain the length of telomeres present at the end of chromosomes. What is the function of telomerase? Telomerase is responsible for preventing the shortening of the end of chr...