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Maintenance of functional telomeres, the highly complex nucleo-protein structures, at the end of linear eukaryotic chromosomes appears to be essential for growth and survival of the cells. The compelling correlation between telomerase re-activation and cellular immortalization led to the idea that ...
Importantly, we also find cancer stem/initiating cells have short telomeres (compared to normal stem cells which have relatively longer telomeres). The short telomeres in cancer stem cells may reflect the multistep nature of cancer initiation and progression. The immediate implications of this new ...
In most cancers, germline and stem cells, long-term proliferation requires telomerase activity to overcome the telomere shortening, which occurs with cell division. This shortening eventually arrests cellular growth, potentially providing an initial proliferative barrier to tumor formation in humans [5]. ...
Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while
We will also review novel telomerase-mediated telomere uncapping approaches that target telomerase-expressing cancer cells, but not normal cells.doi:10.1002/9781119000822.hfcm014Ilgen MenderZeliha Gunnur DikmenWoodring E. WrightJerry W. ShayJohn Wiley & Sons, Inc....
technology to engineer cells with precisely the same mutations as those seen in the Dutch families and examined the resulting mutant cells. She found that the mutant cells had fully functional telomeres and no genomic instability. They were, for all intents and purposes, normal healthy cells. ...
Bmi-1 has been shown to play a key role in maintaining indefinite self-renewal of normal stem and cancer stem cells, a function which must necessarily be linked to maintenance of telomeres in stem cells (discussed below). In summary, it can be safely postulated that HSCs posses a specific ...
myeloid-derived suppressor cells; miRNA: micro RNA; mRNA: messenger RNA; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3: NLR family pyrin domain containing 3; SCFA: short-chain fatty acids; TCR: T cell receptor; TH: helper T cell; TLR: Toll-like receptor;...
telomeres and aging, cancer, and hepatic fibrosistelomere shortening ‐ limiting proliferative capacity of human cellsaging associated with ‐ decreasing organ maintenance, impaired regenerative capacity, and increased cancer riskcheckpoints (mortality stages) limiting lifespan of cells in response to ...