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20,21,22,23]. Functionally, TERT affects cancer formation mostly by maintaining telomere length and enabling cells to avert cell senescence [24]. TERT has other
cancer therapyG-quadrupleximmunotherapyvaccinetargeted gene therapysmall-molecule inhibitorImetelstatGRN163L6-thio-2′-deoxyguanosineFinding specific targeted agents for cancer therapy remains a challenge. One of the hallmarks of cancer is the limitless proliferation (immortalization) of cancer cells, which ...
Inhibition oftelomerase activity in cancer cells using short hairpin RNA expression vectors [ J]. Cancer Invest, 2007, 25(8): 691-8.Chen SM, Tao ZZ, Hua QQ, Xiao BK, Xu Y, Wang Y, et al. Inhibition of telomerase activity in cancer cells using short hairpin RNA expression vectors . ...
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was ... SE Artandi,RA Depinho - Semin Cancer Biol 被引量: 982发表: 2010年 Meeting Report: The Role of Telomeres and Telomerase in Cancer ...
Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while
3. Telomerase in stem cells 4. Background review of cancer stem cells 5. Review of telomerase in cancer stem cells 6. Evidence for short telomeres in cancer stem cells 7. Self-renewal in cancer stem cells versus bulk tumor cells 8. Do cancer initiating/stem cells have different DNA strands...
Telomeres maintain genomic integrity in normal cells, and their progressive shortening during successive cell divisions induces chromosomal instability. In... MA Jafri,SA Ansari,MH Alqahtani,... - 《Genome Medicine》 被引量: 187发表: 2016年 Telomeres and telomerase in cancer stem cells Telomeres ma...
Although most somatic cells do not exhibit telomerase activit... L Han-Woong,R Jae-Il,SY Hoon - 《Oncotargets & Therapy》 被引量: 10发表: 2013年 Telomere Maintenance Mechanisms in Cancer: Clinical Implications The presence of immortal cell populations with an up-regulated telomere maintenance ...
As a consequence, cells enter senescence after a limited number of divisions. The enzyme telomerase expressed in rare cells of the skin, blood and intestine can prevent the shortening of telomeres and extend cellular lifespan. Keywords: cancer; aging; senescence; immortality; telomerase; telomeres...